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Inositol Monophosphatase 2 (IMPA2)

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IMP.18P; Inositol-1(or 4)-monophosphatase 2; Myo-inositol monophosphatase A2

Inositol Monophosphatase 2 (IMPA2)
CCC G834
HGNC 6051
MGI 2149728
PubMed 17251911
RGD 628692
UniProt O14732
Wiki IMPA2
Inositol phosphatases play a crucial role in the phosphatidylinositol signaling pathway. Yoshikawa et al. (1997) cloned myo-inositol monophosphatase-2 (IMPA2) from an EST located in the 18p11.2 region. The deduced 288-amino acid protein shares approximately 54% identity with IMPA1. It contains 2 motifs, designated A and B, that are common to other inositol phosphatases and are thought to be important in metal binding and in the catalytic activity of human IMP.
Northern blot analysis detected expression of a 1.5-kb IMPA2 transcript in many adult and fetal tissues; in brain, the expression is substantially higher in the subcortical regions, most prominently in the caudate.IMPA2 gene contains 8 exons spanning approximately 27 kb of genomic DNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Monophosphatase 2 (IMPA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Monophosphatase 2 (IMPA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Monophosphatase 2 (IMPA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Monophosphatase 2 (IMPA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Monophosphatase 2 (IMPA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Monophosphatase 2 (IMPA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Monophosphatase 2 (IMPA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Monophosphatase 2 (IMPA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Monophosphatase 2 (IMPA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Monophosphatase 2 (IMPA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Monophosphatase 2 (IMPA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Monophosphatase 2 (IMPA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Monophosphatase 2 (IMPA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Monophosphatase 2 (IMPA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Monophosphatase 2 (IMPA2) ELISA Kit Customized Service Offer
  1. "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder."Mol. Psychiatry 2:393-397(1997) [PubMed] [Europe PMC] [Abstract]
  2. "A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients."Mol. Psychiatry 5:172-180(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Lithium modulation of the human inositol monophosphatase 2 (IMPA2) promoter."Biochem. Biophys. Res. Commun. 324:1370-1378(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1."J. Biol. Chem. 282:637-646(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures."Proteins 67:732-742(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of human inositol monophosphatase 2."Submitted (FEB-2009) to the PDB data bank