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Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1)

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ITRPK1; Inositol-tetrakisphosphate 1-kinase

Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1)
CCC G830
HGNC 6177
MGI 2446159
PubMed 22308441
RGD 1595691
UniProt Q13572
Wiki ITPK1
This cDNA encodes a 414-amino acid polypeptide. ITRPK1 was expressed as a 3.6-kb message in all tissues tested, with the highest levels in brain. Expression of the cDNA resulted in inositol 1,3,4-trisphosphate 5/6-kinase activity, showing that a single kinase phosphorylates inositol in both the D5 and D6 positions.
Functional analysis showed that the variant, which they called the type beta protein, as well as the protein with asn356, which they called the type alpha protein, phosphorylated not only the 5- and 6-hydroxy groups of Ins(1,3,4)P3 but also the 1-hydroxy group of Ins(3,4,5,6)P4, suggesting that the 2 inositol phosphates compete for phosphorylation in vivo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol-1,3,4-Triphosphate-5/6-Kinase (ITPK1) ELISA Kit Customized Service Offer
  1. "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme."J. Biol. Chem. 271:11904-11910(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase."Biochem. J. 351:551-555(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2."J. Biol. Chem. 276:40998-41004(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase."Curr. Biol. 12:477-482(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1."J. Biol. Chem. 277:45759-45764(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis."J. Biol. Chem. 278:43645-43653(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase."Biochem. J. 389:389-395(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase."Mol. Cell 18:201-212(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation."Proc. Natl. Acad. Sci. U.S.A. 109:2290-2295(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Integration of inositol phosphate signaling pathways via human ITPK1."J. Biol. Chem. 282:28117-28125(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Structure of human inositol 1,3,4-trisphosphate 5/6-kinase."Submitted (FEB-2007) to the PDB data bank