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Lysine Specific Demethylase 4A (KDM4A)

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JMJD2; JMJD2A; JHDM3A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A

Lysine Specific Demethylase 4A (KDM4A)
CCC G807
HGNC 22978
MGI 2446210
PubMed 23871696
RGD 1306378
UniProt O75164
JMJD2A encodes a deduced 1,064-amino acid protein. Like JMJD2B and JMJD2C, JMJD2A contains a JmjN domain, a JmjC domain, a JD2H domain, 2 TUDOR domains, and a bipartite nuclear localization signal that overlaps the C-terminal part of the second TUDOR domain. JmjN is a small domain found in the Jumonji family of transcription factors. JmjC is a putative enzymatic domain. JD2H is a region containing 2 cys-his clusters with weak similarity to a PHD domain.This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG807Hu01 Recombinant Lysine Specific Demethylase 4A (KDM4A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG807Hu21 Monoclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB; IHC; ICC; IP.
PAG807Hu01 Polyclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) WB,IHC,ICC/IF
Assay Kits SEG807Hu ELISA Kit for Lysine Specific Demethylase 4A (KDM4A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysine Specific Demethylase 4A (KDM4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysine Specific Demethylase 4A (KDM4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysine Specific Demethylase 4A (KDM4A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lysine Specific Demethylase 4A (KDM4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysine Specific Demethylase 4A (KDM4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysine Specific Demethylase 4A (KDM4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysine Specific Demethylase 4A (KDM4A) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein."J. Biol. Chem. 280:28507-28518(2005) [PubMed] [Europe PMC] [Abstract]
  5. "JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2)."Mol. Cell. Biol. 25:6404-6414(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases."Cell 125:467-481(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Tudor, MBT and chromo domains gauge the degree of lysine methylation."EMBO Rep. 7:397-403(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites."EMBO J. 31:1865-1878(2012) [PubMed] [Europe PMC] [Abstract]
  12. "A new isoform of the histone demethylase JMJD2A/KDM4A is required for skeletal muscle differentiation."PLoS Genet. 7:E1001390-E1001390(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Structural insights into histone demethylation by JMJD2 family members."Cell 125:691-702(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Recognition of histone H3 lysine-4 methylation by the double Tudor domain of JMJD2A."Science 312:748-751(2006) [PubMed] [Europe PMC] [Abstract]