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TNF Receptor Associated Factor 3 (TRAF3)

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LAP1; CAP-1; CD40bp; CRAF1; CD40 receptor-associated factor 1; CD40-binding protein; LMP1-associated protein 1

TNF Receptor Associated Factor 3 (TRAF3)
CCC G753
HGNC 12033
MGI 108041
PubMed 20832341
RGD 1304633
UniProt Q13114
Wiki TRAF3
TRAF3 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG753Hu01 Recombinant TNF Receptor Associated Factor 3 (TRAF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG753Hu21 Monoclonal Antibody to TNF Receptor Associated Factor 3 (TRAF3) WB; IHC; ICC; IP.
PAG753Hu01 Polyclonal Antibody to TNF Receptor Associated Factor 3 (TRAF3) WB; IHC; ICC; IP.
Assay Kits SEG753Hu ELISA Kit for TNF Receptor Associated Factor 3 (TRAF3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TNF Receptor Associated Factor 3 (TRAF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TNF Receptor Associated Factor 3 (TRAF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TNF Receptor Associated Factor 3 (TRAF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TNF Receptor Associated Factor 3 (TRAF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for TNF Receptor Associated Factor 3 (TRAF3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TNF Receptor Associated Factor 3 (TRAF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TNF Receptor Associated Factor 3 (TRAF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TNF Receptor Associated Factor 3 (TRAF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TNF Receptor Associated Factor 3 (TRAF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for TNF Receptor Associated Factor 3 (TRAF3) ELISA Kit Customized Service Offer
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  3. "A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40."FEBS Lett. 358:113-118(1995) [PubMed] [Europe PMC] [Abstract]
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  11. "Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily."Biochem. Biophys. Res. Commun. 233:592-600(1997) [PubMed] [Europe PMC] [Abstract]
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  14. "CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization."Biochemistry 37:11836-11845(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation."J. Biol. Chem. 273:5808-5814(1998) [PubMed] [Europe PMC] [Abstract]
  16. "The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor."J. Biol. Chem. 273:28355-28359(1998) [PubMed] [Europe PMC] [Abstract]
  17. "ASK1 is essential for JNK/SAPK activation by TRAF2."Mol. Cell 2:389-395(1998) [PubMed] [Europe PMC] [Abstract]
  18. "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB."Mol. Cell. Biol. 18:558-565(1998) [PubMed] [Europe PMC] [Abstract]
  19. "Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand."J. Biol. Chem. 274:6056-6061(1999) [PubMed] [Europe PMC] [Abstract]
  20. "Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)."Oncogene 18:5814-5820(1999) [PubMed] [Europe PMC] [Abstract]
  21. "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death."J. Biol. Chem. 275:15336-15342(2000) [PubMed] [Europe PMC] [Abstract]
  22. "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation."J. Biol. Chem. 275:18586-18593(2000) [PubMed] [Europe PMC] [Abstract]
  23. "MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network."J. Biol. Chem. 275:23852-23860(2000) [PubMed] [Europe PMC] [Abstract]
  24. "TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase."J. Immunol. 165:1322-1330(2000) [PubMed] [Europe PMC] [Abstract]
  25. "The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A."J. Biol. Chem. 276:2668-2677(2001) [PubMed] [Europe PMC] [Abstract]
  26. "TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation."J. Biol. Chem. 279:55855-55865(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation."J. Biol. Chem. 279:26243-26250(2004) [PubMed] [Europe PMC] [Abstract]
  28. "DUBA: a deubiquitinase that regulates type I interferon production."Science 318:1628-1632(2007) [PubMed] [Europe PMC] [Abstract]
  29. "The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling."J. Biol. Chem. 284:19122-19131(2009) [PubMed] [Europe PMC] [Abstract]
  30. "The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation."PLoS Pathog. 5:E1000650-E1000650(2009) [PubMed] [Europe PMC] [Abstract]
  31. "Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6."J. Biol. Chem. 285:4291-4297(2010) [PubMed] [Europe PMC] [Abstract]
  32. "Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response."J. Biol. Chem. 285:9470-9476(2010) [PubMed] [Europe PMC] [Abstract]
  33. "TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor."J. Biol. Chem. 285:12971-12978(2010) [PubMed] [Europe PMC] [Abstract]
  34. "Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation."Mol. Cell. Biochem. 338:11-17(2010) [PubMed] [Europe PMC] [Abstract]
  35. "Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection."PLoS Pathog. 6:E1000778-E1000778(2010) [PubMed] [Europe PMC] [Abstract]
  36. "Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death."J. Cell. Physiol. 226:3121-3131(2011) [PubMed] [Europe PMC] [Abstract]
  37. "The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity." Immunity 39:111-122(2013) [PubMed] [Europe PMC] [Abstract]
  38. "Molecular basis for CD40 signaling mediated by TRAF3."Proc. Natl. Acad. Sci. U.S.A. 97:10395-10399(2000) [PubMed] [Europe PMC] [Abstract]
  39. "Downstream regulator TANK binds to the CD40 recognition site on TRAF3."Structure 10:403-411(2002) [PubMed] [Europe PMC] [Abstract]
  40. "Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling."J. Biol. Chem. 278:50523-50529(2003) [PubMed] [Europe PMC] [Abstract]
  41. "Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation."J. Immunol. 173:7394-7400(2004) [PubMed] [Europe PMC] [Abstract]
  42. "LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3."J. Biol. Chem. 280:33620-33626(2005) [PubMed] [Europe PMC] [Abstract]
  43. "Solution structure of the zinc finger, C3HC4 type (RING finger) domain of TNF receptor-associated factor 3."Submitted (FEB-2008) to the PDB data bank
  44. "Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis." Immunity 33:400-411(2010) [PubMed] [Europe PMC] [Abstract]