G Protein Coupled Receptor 141 (GPR141)

GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) .CloningBack to Top By searching databases for sequences similar to rhodopsin-like GPRs, Fredriksson et al. (2003) identified GPR141. Fredriksson et al. (2003) mapped the GPR141 gene to chromosome 7p14.1. They mapped the mouse Gpr141 gene to chromosome 13.

The deduced 299-amino acid protein assumes a classic 7-transmembrane (TM) topology. Instead of the DRY motif in the intracellular side of TM3, GPR141 has a TRY motif, and it has no classic NSxxNPxxY motif in TM7. GPR141 shares 67% amino acid identity with mouse Gpr141. EST database analysis indicated that GPR141 is expressed in bone marrow.Fredriksson et al. (2003) determined that the mouse and human GPR141 genes contain a single coding exon.