≡

G Protein Coupled Receptor 132 (GPR132)

[Edit]

G2A; G2 accumulation protein

G Protein Coupled Receptor 132 (GPR132)
CCC G702
HGNC 17482
MGI 1890220
PubMed 24478334
RGD 1310817
UniProt Q9UNW8
Wiki GPR132
GPR132 encodes a subfamily member of the G-protein couple receptor (GPCR) superfamily. The encoded protein is a high-affinity receptor for lysophosphatidylcholine (LPC), a major phospholipid component of oxidized low density lipoprotein. This protein may react to LPC levels at sites of inflammation to limit the expansion of tissue-infiltrating cells. A similar protein in mouse is involved in cell cycle progression.
Sequence analysis predicted that human G2A is a 380-amino acid, 7-membrane-spanning G protein-coupled receptor (GPCR) that is 70% identical to the mouse protein. It contains an N-linked glycosylation site and a putative N-terminal destruction box, which serves as a recognition motif for ubiquitin conjugation, in the first transmembrane domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 132 (GPR132) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 132 (GPR132) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 132 (GPR132) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 132 (GPR132) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 132 (GPR132) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 132 (GPR132) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 132 (GPR132) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 132 (GPR132) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 132 (GPR132) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 132 (GPR132) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 132 (GPR132) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 132 (GPR132) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 132 (GPR132) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 132 (GPR132) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 132 (GPR132) ELISA Kit Customized Service Offer
  1. "A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M."Proc. Natl. Acad. Sci. U.S.A. 95:12334-12339(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and analysis of two splice variants of human G2A generated by alternative splicing."J. Pharmacol. Exp. Ther. 332:469-478(2010) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A."Science 293:702-705(2001) [PubMed] [Europe PMC] [Abstract]
  7. ErratumScience 307:206-206(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques."Arterioscler. Thromb. Vasc. Biol. 22:2049-2053(2002) [PubMed] [Europe PMC] [Abstract]
  9. "The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis."J. Biol. Chem. 278:14379-14386(2003) [PubMed] [Europe PMC] [Abstract]