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G Protein Coupled Receptor 124 (GPR124)

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TEM5; Tumor Endothelial Marker 5

G Protein Coupled Receptor 124 (GPR124)
CCC G699
HGNC 17849
MGI 1925810
PubMed 23329986
UniProt Q96PE1
Wiki GPR124
TEM5 was expressed clearly in the endothelial cells of the tumor stroma but not in the endothelial cells of normal colonic tissue. The authors used in situ hybridization to examine Tem5 expression in murine tumors, embryos, and adult tissues.
The N-terminal extracellular region contains 4 simple leucine-rich repeats (LRRs), a C-terminal LRR, an immunoglobulin-type domain, a hormone receptor domain, and a putative G protein-coupled receptor (GPCR) proteolysis site domain typical of class II family members and required for endogenous proteolysis. TEM5 may be a member of the GPCR superfamily involved in transmitting signals across the cell membrane. The mouse ortholog of TEM5 shares 87% amino acid identity with the human protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 124 (GPR124) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 124 (GPR124) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 124 (GPR124) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 124 (GPR124) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 124 (GPR124) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 124 (GPR124) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 124 (GPR124) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 124 (GPR124) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 124 (GPR124) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 124 (GPR124) ELISA Kit Customized Service Offer
  1. "Cell surface tumor endothelial markers are conserved in mice and humans."Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein."Oncogene 23:3889-3897(2004) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation."Hum. Mol. Genet. 23:3481-3489(2014) [PubMed] [Europe PMC] [Abstract]
  12. "POMK mutations disrupt muscle development leading to a spectrum of neuromuscular presentations."Hum. Mol. Genet. 23:5781-5792(2014) [PubMed] [Europe PMC] [Abstract]