Zinc Finger Protein 182 (ZNF182)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TF_IIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.

Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. Knight et al. (1994) localized the ZNF21 gene to Xp22.11-p11.23 in a cluster of zinc finger protein genes. The ZNF21 gene had previously been mapped to Xp by Huebner et al. (1991). Stoddart et al. (1999) mapped the ZNF21 gene to Xp11.3 by inclusion within a YAC contig.