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RNA Binding Motif Protein 4 (RBM4)

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LARK; RBM4A; ZCCHC21; ZCRB3A

RNA Binding Motif Protein 4 (RBM4)
CCC G654
HGNC 9901
MGI 1100865
PubMed 21518792
RGD 1306891
UniProt Q9BWF3
Wiki RBM4
RBM4 encodes a member of the RNA recognition motif (RRM) class of RNA-binding proteins and is essential for embryonic development. Jackson et al. (1997) identified a human EST that has significant homology to lark.
The human gene, called 'RNA-binding motif protein-4' (RBM4), encodes a predicted 366-amino acid protein that contains 2 RRM-type RNA-binding motifs and a retroviral-type (RT) zinc finger. In the N-terminal segment, the amino acid sequence of RBM4 is 50% identical to that of lark. Jackson et al. (1997) also identified mouse Rbm4 ESTs and found that the encoded protein is virtually identical to human RBM4. By Northern blotting, human RBM4 was expressed as a 1.8-kb mRNA in all tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Binding Motif Protein 4 (RBM4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Binding Motif Protein 4 (RBM4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Binding Motif Protein 4 (RBM4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Binding Motif Protein 4 (RBM4) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Binding Motif Protein 4 (RBM4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Binding Motif Protein 4 (RBM4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Binding Motif Protein 4 (RBM4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Binding Motif Protein 4 (RBM4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Binding Motif Protein 4 (RBM4) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Binding Motif Protein 4 (RBM4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Binding Motif Protein 4 (RBM4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Binding Motif Protein 4 (RBM4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Binding Motif Protein 4 (RBM4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Binding Motif Protein 4 (RBM4) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Binding Motif Protein 4 (RBM4) ELISA Kit Customized Service Offer
  1. "A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans."Genomics 41:444-452(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain."Proteomics 2:1752-1757(2002) [PubMed] [Europe PMC] [Abstract]
  7. "A novel splicing regulator shares a nuclear import pathway with SR proteins."EMBO J. 22:1359-1369(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB."Mol. Cell. Biol. 25:10111-10121(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Lark is the splicing factor RBM4 and exhibits unique subnuclear localization properties."DNA Cell Biol. 25:457-464(2006) [PubMed] [Europe PMC] [Abstract]
  11. "WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo."Exp. Cell Res. 312:3379-3388(2006) [PubMed] [Europe PMC] [Abstract]
  12. "RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion."J. Biol. Chem. 281:24479-24488(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Cell stress modulates the function of splicing regulatory protein RBM4 in translation control."Proc. Natl. Acad. Sci. U.S.A. 104:2235-2240(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  16. "The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum."Neurosci. Lett. 444:11-15(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation."J. Biol. Chem. 284:34658-34665(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins."Nat. Biotechnol. 27:667-670(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing."J. Cell Biol. 193:509-520(2011) [PubMed] [Europe PMC] [Abstract]
  23. "RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site."Mol. Cell. Biol. 31:1812-1821(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Solution structure of RNA binding domain 1 in RNA-binding protein 30."Submitted (OCT-2006) to the PDB data bank