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Transcription factor 7 (TCF7)

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TCF-1,T-Cell Specific,HMG-Box; T-cell-specific transcription factor 1

Transcription factor 7 (TCF7)
CCC G642
HGNC 11639
MGI 98507
PubMed 15765502
RGD 1305894
UniProt P36402
Wiki TCF7
Three of the genes determining subunits of the CD3 complex, CD3-gamma (CD3G), CD3-delta (CD3D), and CD3-epsilon (CD3E), are tightly clustered in a stretch of 60 kb of DNA on human chromosome 11q23. This tight clustering might suggest that the CD3 genes are controlled by a single cis-acting element.
The most abundant TCF7 isoforms lack a beta-catenin interaction domain. TCF7 -/- mice develop adenomas in the gut and mammary glands. Introduction of a mutant APC allele into these mice substantially increases the number of these adenomas. TCF7 may act as a feedback repressor of beta-catenin TCF4 (TCF7L2) target genes and thus may cooperate with APC to suppress malignant transformation of epithelial cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription factor 7 (TCF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription factor 7 (TCF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription factor 7 (TCF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription factor 7 (TCF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription factor 7 (TCF7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription factor 7 (TCF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription factor 7 (TCF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription factor 7 (TCF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription factor 7 (TCF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription factor 7 (TCF7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription factor 7 (TCF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription factor 7 (TCF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription factor 7 (TCF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription factor 7 (TCF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription factor 7 (TCF7) ELISA Kit Customized Service Offer
  1. "Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box."EMBO J. 10:123-132(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization."J. Biol. Chem. 267:8530-8536(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA."Biochim. Biophys. Acta 1263:169-172(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1."Science 285:1923-1926(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties."Mol. Cell. Biol. 16:745-752(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Two members of the Tcf family implicated in Wnt/b-catenin signaling during embryogenesis in the mouse."Mol. Cell. Biol. 18:1248-1256(1998) [PubMed] [Europe PMC] [Abstract]
  9. "The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors."Nature 395:608-612(1998) [PubMed] [Europe PMC] [Abstract]
  10. "All Tcf HMG box transcription factors interact with Groucho-related co-repressors."Nucleic Acids Res. 29:1410-1419(2001) [PubMed] [Europe PMC] [Abstract]