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Transcription factor 12 (TCF12)

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HEB; HTF4; bHLHb20; Helix-Loop-Helix Transcription Factor 4; Class B basic helix-loop-helix protein 20; DNA-binding protein HTF4; E-box-binding protein

Transcription factor 12 (TCF12)
CCC G640
HGNC 11623
MGI 101877
PubMed 23354436
RGD 3829
UniProt Q99081
Wiki TCF12
TCF12 is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
HEBAlt includes the bHLH domain and activation domain-2 (AD2) of canonical HEB (HEBCan), but it replaces AD1 with an alternative domain homologous to the N-terminal region of the ITF2A variant of ITF2 (TCF4).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription factor 12 (TCF12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription factor 12 (TCF12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription factor 12 (TCF12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription factor 12 (TCF12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription factor 12 (TCF12) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription factor 12 (TCF12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription factor 12 (TCF12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription factor 12 (TCF12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription factor 12 (TCF12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription factor 12 (TCF12) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription factor 12 (TCF12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription factor 12 (TCF12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription factor 12 (TCF12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription factor 12 (TCF12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription factor 12 (TCF12) ELISA Kit Customized Service Offer
  1. "The nucleotide sequence of the human transcription factor HTF4a cDNA."DNA Seq. 2:397-403(1992) [PubMed] [Europe PMC] [Abstract]
  2. "HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors."Mol. Cell. Biol. 12:1031-1042(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "HTF4: a new human helix-loop-helix protein."Nucleic Acids Res. 19:4555-4555(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Genomic organization of human TCF12 gene and spliced mRNA variants producing isoforms of transcription factor HTF4."Cytogenet. Genome Res. 98:245-248(2002) [PubMed] [Europe PMC] [Abstract]
  9. "The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity."Cancer Cell 9:249-260(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Nine-amino-acid transactivation domain: establishment and prediction utilities."Genomics 89:756-768(2007) [PubMed] [Europe PMC] [Abstract]
  12. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity."Blood 113:3558-3567(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis." Nat. Genet. 45:304-307(2013) [PubMed] [Europe PMC] [Abstract]
  21. "Expanding the mutation spectrum in 182 Spanish probands with craniosynostosis: identification and characterization of novel TCF12 variants."Eur. J. Hum. Genet. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]