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Arylsulfatase K (ARSK)

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TSULF; ASK; Telethon sulfatase

Arylsulfatase K (ARSK)
CCC G618
HGNC 25239
MGI 1924291
PubMed 23986440
RGD 1310182
UniProt Q6UWY0
Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules .
By searching databases for novel sulfatase genes, Sardiello et al. (2005) and Obaya (2006) identified ARSK. They determined that all human sulfatases, including ARSK, have 9 regions of strong evolutionary conservation, most of which contain residues involved in the sulfatase hydrolysis reaction.
Western blot analysis of HeLa cells expressing epitope-tagged ARSK detected the protein only in the particulate fraction, suggesting ARSK associates with cellular organelles or membrane structures.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arylsulfatase K (ARSK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arylsulfatase K (ARSK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arylsulfatase K (ARSK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arylsulfatase K (ARSK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arylsulfatase K (ARSK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arylsulfatase K (ARSK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arylsulfatase K (ARSK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arylsulfatase K (ARSK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arylsulfatase K (ARSK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arylsulfatase K (ARSK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arylsulfatase K (ARSK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arylsulfatase K (ARSK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arylsulfatase K (ARSK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arylsulfatase K (ARSK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arylsulfatase K (ARSK) ELISA Kit Customized Service Offer
  1. "Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship."Hum. Mol. Genet. 14:3203-3217(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and initial characterization of three novel human sulfatases."Gene 372:110-117(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]