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Glucosidase Beta, Bile Acid 2 (GbA2)

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Bile Acid Beta-Glucosidase; Non-Lysosomal Glucosylceramidase; Beta-glucocerebrosidase 2; Glucosylceramidase 2

Glucosidase Beta, Bile Acid 2 (GbA2)
CCC G604
HGNC 18986
MGI 2654325
PubMed 23332917
RGD 1305598
UniProt Q9HCG7
Wiki GBA2
GBA2 encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism.
The deduced protein contains 927 amino acids and has a calculated molecular mass of 104.6 kD. GBA2 contains a putative membrane-spanning domain and 2 potential N-glycosylation sites. However, glycosidase treatment indicated that GBA2 is not a glycoprotein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glucosidase Beta, Bile Acid 2 (GbA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucosidase Beta, Bile Acid 2 (GbA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucosidase Beta, Bile Acid 2 (GbA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glucosidase Beta, Bile Acid 2 (GbA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucosidase Beta, Bile Acid 2 (GbA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glucosidase Beta, Bile Acid 2 (GbA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucosidase Beta, Bile Acid 2 (GbA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucosidase Beta, Bile Acid 2 (GbA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glucosidase Beta, Bile Acid 2 (GbA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucosidase Beta, Bile Acid 2 (GbA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glucosidase Beta, Bile Acid 2 (GbA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucosidase Beta, Bile Acid 2 (GbA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucosidase Beta, Bile Acid 2 (GbA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glucosidase Beta, Bile Acid 2 (GbA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucosidase Beta, Bile Acid 2 (GbA2) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of human bile acid beta -glucosidase."J. Biol. Chem. 276:37929-37933(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Purification and characterization of a microsomal bile acid beta-glucosidase from human liver."J. Biol. Chem. 272:11261-11267(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2."J. Biol. Chem. 282:1305-1312(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Loss of function of glucocerebrosidase GBA2 is responsible for motor neuron defects in hereditary spastic paraplegia." Am. J. Hum. Genet. 92:238-244(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in GBA2 cause autosomal-recessive cerebellar ataxia with spasticity."Am. J. Hum. Genet. 92:245-251(2013) [PubMed] [Europe PMC] [Abstract]