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Solute Carrier Family 34, Member 3 (SLC34A3)

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NPTIIc; Sodium-dependent phosphate transport protein 2C; Na(+)-dependent phosphate cotransporter 2C; Sodium/inorganic phosphate cotransporter IIC

Solute Carrier Family 34, Member 3 (SLC34A3)
CCC G572
HGNC 20305
MGI 2159410
PubMed 22695891
RGD 708551
UniProt Q8N130
Wiki SLC34A3
SLC34A3 is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria.
Slc34a3 expression was highest in brush border membrane vesicles obtained from weaning rats. Expression was lower in adult rats and lowest in suckling rats. Immunohistochemical analysis of kidneys from weaning rats detected Slc34a3 in the brush border of juxtamedullary proximal tubular cells. Levels were lower in proximal tubular cells of superficial nephrons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 34, Member 3 (SLC34A3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 34, Member 3 (SLC34A3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 34, Member 3 (SLC34A3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 34, Member 3 (SLC34A3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 34, Member 3 (SLC34A3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 34, Member 3 (SLC34A3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 34, Member 3 (SLC34A3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 34, Member 3 (SLC34A3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 34, Member 3 (SLC34A3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 34, Member 3 (SLC34A3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 34, Member 3 (SLC34A3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 34, Member 3 (SLC34A3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 34, Member 3 (SLC34A3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 34, Member 3 (SLC34A3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 34, Member 3 (SLC34A3) ELISA Kit Customized Service Offer
  1. "Growth-related renal type II Na/Pi cotransporter."J. Biol. Chem. 277:19665-19672(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis."Am. J. Hum. Genet. 78:179-192(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3."Am. J. Hum. Genet. 78:193-201(2006) [PubMed] [Europe PMC] [Abstract]