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Phosphatidylethanolamine-N-Methyltransferase (PEMT)

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PEMPT; PEMT2

Phosphatidylethanolamine-N-Methyltransferase (PEMT)
CCC G540
HGNC 8830
MGI 104535
PubMed 24595004
RGD 3297
UniProt Q9UBM1
Wiki PEMT
PEMT encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. The protein localizes to the endoplasmic reticulum and mitochondria-associated membranes. The gene is within the Smith-Magenis syndrome region on chromosome 17. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.
Two isoforms of PEMT appear to exist: PEMT1, localized to the endoplasmic reticulum and generating most of the PEMT activity, and PEMT2, corresponding to the cloned cDNA, which resides on mitochondria-associated membranes. Both enzymes are capable of catalyzing all 3 methylation steps.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylethanolamine-N-Methyltransferase (PEMT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylethanolamine-N-Methyltransferase (PEMT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylethanolamine-N-Methyltransferase (PEMT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylethanolamine-N-Methyltransferase (PEMT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylethanolamine-N-Methyltransferase (PEMT) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylethanolamine-N-Methyltransferase (PEMT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylethanolamine-N-Methyltransferase (PEMT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylethanolamine-N-Methyltransferase (PEMT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylethanolamine-N-Methyltransferase (PEMT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylethanolamine-N-Methyltransferase (PEMT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylethanolamine-N-Methyltransferase (PEMT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylethanolamine-N-Methyltransferase (PEMT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylethanolamine-N-Methyltransferase (PEMT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylethanolamine-N-Methyltransferase (PEMT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylethanolamine-N-Methyltransferase (PEMT) ELISA Kit Customized Service Offer
  1. "Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2."Biochim. Biophys. Acta 1436:405-412(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Structure, expression profile and alternative processing of the human phosphatidylethanolamine N-methyltransferase (PEMT) gene."Biochim. Biophys. Acta 1532:105-114(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes."FASEB J. 21:2622-2632(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Functional analysis of two isoforms of phosphatidylethanolamine N-methyltransferase."Biochem. J. 432:387-398(2010) [PubMed] [Europe PMC] [Abstract]