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V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN)

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JTK8; p53Lyn; p56Lyn; Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase

V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN)
CCC G523
HGNC 6735
MGI 96892
PubMed 3561390
RGD 621017
UniProt P07948
Wiki LYN
Using a v-yes DNA as the probe, Yamanashi et al. (1987) screened a human cDNA library made from placental RNA and derived DNA clones representing a novel genetic locus termed LYN. Nucleotide sequencing showed that LYN encodes a novel tyrosine kinase. Northern hybridization analysis showed that a 3.2-kb LYN mRNA was expressed in a variety of tissues of the human fetus. The pattern of expression was different from those of related genes such as YES.The degranulation response was dependent on a rise in intracellular calcium that was inhibited in Lyn-deficient mast cells but intact in Fyn-deficient cells. Degranulation proceeded in Lyn -/- cells due to increased activation and constitutive phosphorylation of the calcium-independent protein kinase C delta isoform (PRKCD).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG523Hu01 Recombinant V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG523Hu01 Polyclonal Antibody to V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) WB; IHC; ICC; IP.
MAG523Hu21 Monoclonal Antibody to V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) WB; IHC; ICC; IP.
Assay Kits SEG523Hu ELISA Kit for V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) ELISA Kit Customized Service Offer
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