Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1)

Receptor Tyrosine Kinase Like Orphan Receptor 1 is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. Alternative splicing results in multiple transcript variants encoding different isoforms.

NTRKR1 encodes a predicted 937-amino acid protein. By Northern blot analysis, Reddy et al. (1996) showed that a 6-kb NTRKR1 mRNA is expressed strongly in human heart, lung, and kidney, but weakly in the CNS. However, a truncated 2.4-kb mRNA lacking extracellular and transmembrane domains was strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm