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RAN Binding Protein 3 (RANBP3)

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RAN Binding Protein 3 (RANBP3)
CCC G519
HGNC 9850
MGI 1919060
PubMed 23303829
RGD 1589604
UniProt Q9H6Z4
Wiki RANBP3
The RAN GTPase plays an essential role in the transport of macromolecules between the cytoplasm and the nucleus. The nucleotide-bound state of RAN is regulated by RANGAP1, a RAN-specific GTPase activating protein, and by RCC1 (CHC1), a specific guanine nucleotide exchange factor.
RANBP3 encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.RANBP3 formed a trimeric RCC1-RAN-RANBP3 complex, although it did not bind RCC1 directly. Northern blot analysis revealed that RANBP3 is expressed ubiquitously as 1.8- and 3-kb mRNAs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAN Binding Protein 3 (RANBP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAN Binding Protein 3 (RANBP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAN Binding Protein 3 (RANBP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAN Binding Protein 3 (RANBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAN Binding Protein 3 (RANBP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAN Binding Protein 3 (RANBP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAN Binding Protein 3 (RANBP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAN Binding Protein 3 (RANBP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAN Binding Protein 3 (RANBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAN Binding Protein 3 (RANBP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAN Binding Protein 3 (RANBP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAN Binding Protein 3 (RANBP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAN Binding Protein 3 (RANBP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAN Binding Protein 3 (RANBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAN Binding Protein 3 (RANBP3) ELISA Kit Customized Service Offer
  1. "Human RanBP3, a group of nuclear RanGTP binding proteins."FEBS Lett. 427:330-336(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "RanBP3 influences interactions between CRM1 and its nuclear protein export substrates."EMBO Rep. 2:926-932(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export."J. Cell Biol. 153:1391-1402(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor."J. Biol. Chem. 277:17385-17388(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling."Dev. Cell 16:345-357(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of the RAN_BP1 domain of RAN-binding protein-3."Submitted (NOV-2005) to the PDB data bank