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Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3)

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RP3; EB3; EBF3; EBF3-S; EB1 protein family member 3; End-binding protein 3

Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3)
CCC G493
HGNC 6892
MGI 2140967
PubMed 20829563
RGD 1359297
UniProt Q9UPY8
Wiki MAPRE3
MAPRE3 is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene.
The predicted 282-amino acid protein is 54% identical to MAPRE1. Northern blot analysis revealed expression of a 2.2-kb transcript predominantly in brain and muscle. GST pull-down analysis determined that a homologous region in the C termini of APC and APCL binds to MAPRE3. Immunofluorescence and confocal microscopy demonstrated that MAPRE3 is localized in the microtubule network and colocalizes with APCL in the perinucleus and microtubule network.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Associated Protein RP/EB Family, Member 3 (MAPRE3) ELISA Kit Customized Service Offer
  1. "EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue."Oncogene 19:210-216(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of human MAPRE genes and their proteins."Genomics 71:142-149(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells."J. Immunol. 159:1276-1283(1997) [PubMed] [Europe PMC] [Abstract]
  6. "EB/RP gene family encodes tubulin binding proteins."Int. J. Cancer 81:275-284(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of functional domains of human EB1 family proteins."J. Biol. Chem. 278:49721-49731(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition."Proc. Natl. Acad. Sci. U.S.A. 104:10346-10351(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity."Neuron 61:85-100(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase."J. Cell Biol. 193:1083-1099(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Solution structure of the CH domain of human microtubule-associated protein RP/EB family member 3."Submitted (AUG-2005) to the PDB data bank
  14. "Mammalian end binding proteins control persistent microtubule growth."J. Cell Biol. 184:691-706(2009) [PubMed] [Europe PMC] [Abstract]