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Microtubule Associated Protein RP/EB Family, Member 2 (MAPRE2)

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RP1; EB1; EB2; APC-Binding Protein EB1; End-binding protein 2

Microtubule Associated Protein RP/EB Family, Member 2 (MAPRE2)
CCC G492
HGNC 6891
MGI 106271
PubMed 23561263
UniProt Q15555
Wiki MAPRE2
MAPRE2 shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.
The deduced 327-amino acid protein has significant homology with EB1 family proteins. Northern blot analysis detected a 2.6-kb transcript in T cells activated by 2 signals (i.e., cell surface antigen(s) and/or cytokine) and also in lymphocyte tumor cell lines. Immunoprecipitation analysis indicated that RP1 associates with full-length but not C terminus-deleted APC.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Associated Protein RP/EB Family, Member 2 (MAPRE2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Associated Protein RP/EB Family, Member 2 (MAPRE2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Associated Protein RP/EB Family, Member 2 (MAPRE2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Associated Protein RP/EB Family, Member 2 (MAPRE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Associated Protein RP/EB Family, Member 2 (MAPRE2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Associated Protein RP/EB Family, Member 2 (MAPRE2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Associated Protein RP/EB Family, Member 2 (MAPRE2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Associated Protein RP/EB Family, Member 2 (MAPRE2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Associated Protein RP/EB Family, Member 2 (MAPRE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Associated Protein RP/EB Family, Member 2 (MAPRE2) ELISA Kit Customized Service Offer
  1. "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells."J. Immunol. 159:1276-1283(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "EB/RP gene family encodes tubulin binding proteins."Int. J. Cancer 81:275-284(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of functional domains of human EB1 family proteins."J. Biol. Chem. 278:49721-49731(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]