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Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)

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ARTS1; ALAP; PILSAP; ERAAP1; Aminopeptidase Regulator Of TNFR1 Shedding; Adipocyte-Derived Leucine Aminopeptidase; Puromycin-Insensitive Leucyl-Specific Aminopeptidase

Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)
CCC G457
HGNC 18173
MGI 1933403
PubMed 15908954
RGD 708542
UniProt Q9NZ08
Wiki ARTS-1
Aminopeptidases play a role in the metabolism of several peptides that may be involved in blood pressure and the pathogenesis of essential hypertension . Adipocyte-derived leucine aminopeptidase (ALAP) is a member of the M1 family of zinc metallopeptidases.
The deduced 941-amino acid protein contains an N-terminal signal peptide, 5 potential N-glycosylation sites, a potential membrane-spanning domain, and a zinc-binding motif. Northern blot analysis revealed expression of 3.6- and 5.1-kb transcripts in all tissues tested except brain, where only the 5.1-kb mRNA was expressed. An additional 5.6-kb transcript was expressed in spleen and ovary.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase."J. Biochem. 125:931-938(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of the human adipocyte-derived leucine aminopeptidase gene and its relationship to the placental leucine aminopeptidase/oxytocinase gene."J. Biochem. 130:235-241(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells."J. Biochem. 128:755-762(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum."Nat. Immunol. 6:689-697(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a 'molecular ruler' mechanism."Proc. Natl. Acad. Sci. U.S.A. 102:17107-17112(2005) [PubMed] [Europe PMC] [Abstract]
  10. "An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release."Biochem. Biophys. Res. Commun. 371:505-509(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of the soluble domain of human endoplasmic reticulum aminopeptidase 1 ERAP1."Submitted (MAY-2010) to the PDB data bank
  15. "Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1."Nat. Struct. Mol. Biol. 18:604-613(2011) [PubMed] [Europe PMC] [Abstract]