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GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1)

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Gec1; APG8L; ATG8L; Early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; Glandular epithelial cell protein 1

GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1)
CCC G401
HGNC 4068
MGI 1914980
PubMed 23690988
RGD 1596143
UniProt Q9H0R8
Apg8 is a ubiquitin-like protein involved in autophagy in yeast. A cysteine protease, Apg4, cleaves Apg8 to create a C-terminal glycine required for ubiquitin-like modification reactions. There are at least 4 mammalian Apg8 homologs: GATE16 (GABARAPL2), GABARAP, MAP1LC3, and APG8L.
GABARAPL1 transcript expressed in all tissues examined, with highest levels in brain, heart, peripheral blood leukocytes, liver, kidney, placenta, and skeletal muscle. Moderate expression was found in pancreas, prostate, testis, ovary, lung, spleen, and colon, and low expression was found in thymus and small intestine. In addition, a 4.2-kb transcript was found in low abundance in ovary, peripheral blood leukocytes, and liver, and a 1.7-kb transcript was found in placenta at low levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for GABA-A Receptor Associated Protein Like Protein 1 (GABARAPL1) ELISA Kit Customized Service Offer
  1. "A novel early estrogen-regulated gene gec1 encodes a protein related to GABARAP."Biochem. Biophys. Res. Commun. 284:118-125(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein."Genomics 74:408-413(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor."J. Biol. Chem. 281:7983-7993(2006) [PubMed] [Europe PMC] [Abstract]
  8. "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy."J. Biol. Chem. 282:24131-24145(2007) [PubMed] [Europe PMC] [Abstract]
  9. "GABARAPL1 (GEC1) associates with autophagic vesicles."Autophagy 6:495-505(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Network organization of the human autophagy system."Nature 466:68-76(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins."Autophagy 8:1724-1740(2012) [PubMed] [Europe PMC] [Abstract]
  13. "ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs."J. Biol. Chem. 287:39275-39290(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers."Mol. Cell. Biol. 32:1733-1744(2012) [PubMed] [Europe PMC] [Abstract]
  15. "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."PLoS ONE 7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]
  16. "The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation."Science 338:1072-1076(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1."PLoS ONE 8:E63133-E63133(2013) [PubMed] [Europe PMC] [Abstract]
  18. "Crystal structure of human gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAP1)."Submitted (SEP-2007) to the PDB data bank