Acetoacetyl Coenzyme A Synthetase (AACS)

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SUR-5; ACSF1; Protein sur-5 homolog; Acyl-CoA synthetase family member 1

Acetoacetyl Coenzyme A Synthetase (AACS)
The activity of acetoacetyl-CoA synthetase, a cytoplasmic enzyme that activates acetoacetate, was found to be highly regulated by modulators known to affect the activity of 3-hydroxy-3-methylglutaryl-CoA reductase and/or cholesterol biosynthesis in liver and adrenals of adult rats. Acetoacetyl-CoA synthetase activity was depressed by feeding cholesterol or mevalonate administration and was enhanced by the addition to the diet of mevinolin and/or cholestyramine. The activity of acetoacetyl-CoA synthetase in adrenals was enhanced by treatment of the animals with 4-aminopyrazolopyrimidine. These changes in activity of acetoacetyl-CoA synthetase were in synchrony with changes in the activities of 3-hydroxy-3-methylglutaryl-CoA synthase and 3-hydroxy-3-methylglutaryl-CoA reductase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG352Hu01 Recombinant Acetoacetyl Coenzyme A Synthetase (AACS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Acetoacetyl Coenzyme A Synthetase (AACS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acetoacetyl Coenzyme A Synthetase (AACS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acetoacetyl Coenzyme A Synthetase (AACS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acetoacetyl Coenzyme A Synthetase (AACS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG352Mu01 Recombinant Acetoacetyl Coenzyme A Synthetase (AACS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG352Mu01 Polyclonal Antibody to Acetoacetyl Coenzyme A Synthetase (AACS) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Acetoacetyl Coenzyme A Synthetase (AACS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acetoacetyl Coenzyme A Synthetase (AACS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acetoacetyl Coenzyme A Synthetase (AACS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acetoacetyl Coenzyme A Synthetase (AACS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acetoacetyl Coenzyme A Synthetase (AACS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acetoacetyl Coenzyme A Synthetase (AACS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acetoacetyl Coenzyme A Synthetase (AACS) ELISA Kit Customized Service Offer
  1. "Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain."Biochem. Pharmacol. 65:989-994(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction."Mol. Cell. Biol. 18:4556-4564(1998) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome."J. Lipid Res. 48:2736-2750(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]