Acetoacetyl Coenzyme A Synthetase (AACS)
[Edit]SUR-5; ACSF1; Protein sur-5 homolog; Acyl-CoA synthetase family member 1
The activity of acetoacetyl-CoA synthetase, a cytoplasmic enzyme that activates acetoacetate, was found to be highly regulated by modulators known to affect the activity of 3-hydroxy-3-methylglutaryl-CoA reductase and/or cholesterol biosynthesis in liver and adrenals of adult rats. Acetoacetyl-CoA synthetase activity was depressed by feeding cholesterol or mevalonate administration and was enhanced by the addition to the diet of mevinolin and/or cholestyramine. The activity of acetoacetyl-CoA synthetase in adrenals was enhanced by treatment of the animals with 4-aminopyrazolopyrimidine. These changes in activity of acetoacetyl-CoA synthetase were in synchrony with changes in the activities of 3-hydroxy-3-methylglutaryl-CoA synthase and 3-hydroxy-3-methylglutaryl-CoA reductase.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPG352Hu01 | Recombinant Acetoacetyl Coenzyme A Synthetase (AACS) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Acetoacetyl Coenzyme A Synthetase (AACS) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Acetoacetyl Coenzyme A Synthetase (AACS) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Acetoacetyl Coenzyme A Synthetase (AACS) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Acetoacetyl Coenzyme A Synthetase (AACS) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPG352Mu01 | Recombinant Acetoacetyl Coenzyme A Synthetase (AACS) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAG352Mu01 | Polyclonal Antibody to Acetoacetyl Coenzyme A Synthetase (AACS) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Acetoacetyl Coenzyme A Synthetase (AACS) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Acetoacetyl Coenzyme A Synthetase (AACS) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Acetoacetyl Coenzyme A Synthetase (AACS) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Acetoacetyl Coenzyme A Synthetase (AACS) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Acetoacetyl Coenzyme A Synthetase (AACS) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Acetoacetyl Coenzyme A Synthetase (AACS) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Acetoacetyl Coenzyme A Synthetase (AACS) | ELISA Kit Customized Service Offer |
- "Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain."Biochem. Pharmacol. 65:989-994(2003) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction."Mol. Cell. Biol. 18:4556-4564(1998) [PubMed] [Europe PMC] [Abstract]
- "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
- "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome."J. Lipid Res. 48:2736-2750(2007) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]