V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF)

[Edit]

A-RAF; ARAF1; PKS2; PKS; Serine/threonine-protein kinase A-Raf

V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF)
This sequence, which they called PKS (presumably for 'protein kinase sequence'), showed 71% nucleotide homology to RAF1. The predicted amino acid sequence of the kinase domain was sufficiently like the sequence of v-raf to suggest that PKS may encode a polypeptide with serine/threonine kinase activity.
Mark et al. (1986) found that expression of PKS mRNA (2.7 kb) was elevated in peripheral blood mononuclear cells isolated from 2 patients with angioimmunoblastic lymphadenopathy with dysproteinemia, a disease in which autoantibodies are produced following the lymphoproliferative activation of B cells.As an initial step in the analysis of this RAF1-related cDNA, they isolated a human ARAF cDNA and used it to map the genes in mouse and man.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG346Hu01 Recombinant V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF) ELISA Kit Customized Service Offer
  1. "The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus."Nucleic Acids Res. 15:595-609(1987) [PubMed] [Europe PMC] [Abstract]
  2. "The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1)."Genomics 20:43-55(1994) [PubMed] [Europe PMC] [Abstract]
  3. "DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation."J. Cell Biol. 177:781-793(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Pks, a raf-related sequence in humans."Proc. Natl. Acad. Sci. U.S.A. 83:6312-6316(1986) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of TH1 as an interaction partner of A-Raf kinase."Mol. Cell. Biochem. 231:69-74(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12."Nat. Cell Biol. 14:686-696(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Solution structure of the N-terminal RAS-binding domain (RBD) in human A-RAF kinase."Submitted (JUL-2005) to the PDB data bank
  20. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]