Corin (CRN)
[Edit]ATC2; CRN; Lrp4; TMPRSS10; Atrial Natriuretic Peptide-Converting Enzyme, Serine Protease; Heart-specific serine proteinase ATC2; Pro-ANP-converting enzyme
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Corin encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.
The corin cDNA encodes a deduced 1,042-amino acid, type II transmembrane protein. At its N terminus, corin contains a short cytoplasmic domain and a transmembrane sequence. In the extracellular region of corin, there are 2 frizzled-like cysteine-rich motifs, 7 low density lipoprotein receptor repeats, a macrophage scavenger receptor-like domain, and a trypsin-like protease domain at the C terminus.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG316Hu01 | Recombinant Corin (CRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPG316Hu02 | Recombinant Corin (CRN) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPG316Hu03 | Recombinant Corin (CRN) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPG316Hu04 | Recombinant Corin (CRN) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAG316Hu01 | Polyclonal Antibody to Corin (CRN) | WB; IHC; ICC; IP. |
| MAG316Hu21 | Monoclonal Antibody to Corin (CRN) | WB; IHC; ICC; IP. | |
| PAG316Hu02 | Polyclonal Antibody to Corin (CRN) | WB; IHC; ICC; IP. | |
| PAG316Hu03 | Polyclonal Antibody to Corin (CRN) | WB; IHC; ICC; IP. | |
| PAG316Hu04 | Polyclonal Antibody to Corin (CRN) | WB; IHC; ICC; IP. | |
| Assay Kits | SEG316Hu | ELISA Kit for Corin (CRN) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| CEG316Hu | ELISA Kit for Corin (CRN) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG316Mu01 | Recombinant Corin (CRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPG316Mu02 | Recombinant Corin (CRN) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAG316Mu01 | Polyclonal Antibody to Corin (CRN) | WB; IHC; ICC; IP. |
| PAG316Mu02 | Polyclonal Antibody to Corin (CRN) | WB; IHC; ICC; IP. | |
| Assay Kits | SEG316Mu | ELISA Kit for Corin (CRN) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG316Ra01 | Recombinant Corin (CRN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAG316Ra01 | Polyclonal Antibody to Corin (CRN) | WB; IHC; ICC; IP. |
| LAG316Ra71 | Biotin-Linked Polyclonal Antibody to Corin (CRN) | WB; IHC; ICC. | |
| MAG316Ra21 | Monoclonal Antibody to Corin (CRN) | WB; IHC; ICC; IP. | |
| Assay Kits | SEG316Ra | ELISA Kit for Corin (CRN) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart."J. Biol. Chem. 274:14926-14935(1999) [PubMed] [Europe PMC] [Abstract]
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Localization of the mosaic transmembrane serine protease corin to heart myocytes."Eur. J. Biochem. 267:6931-6937(2000) [PubMed] [Europe PMC] [Abstract]
- "Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme."Proc. Natl. Acad. Sci. U.S.A. 97:8525-8529(2000) [PubMed] [Europe PMC] [Abstract]
- "Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin."J. Biol. Chem. 278:52363-52370(2003) [PubMed] [Europe PMC] [Abstract]
- "Role of glycosylation in corin zymogen activation."J. Biol. Chem. 282:27728-27735(2007) [PubMed] [Europe PMC] [Abstract]
- "Enzyme-linked immunoabsorbent assay for detection of human serine protease corin in blood."Clin. Chim. Acta 409:85-89(2009) [PubMed] [Europe PMC] [Abstract]
- "Ectodomain shedding and autocleavage of the cardiac membrane protease corin."J. Biol. Chem. 286:10066-10072(2011) [PubMed] [Europe PMC] [Abstract]
- "Human corin isoforms with different cytoplasmic tails that alter cell surface targeting."J. Biol. Chem. 286:20963-20969(2011) [PubMed] [Europe PMC] [Abstract]
- "Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy."Nature 484:246-250(2012) [PubMed] [Europe PMC] [Abstract]
- "An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss."Hum. Mutat. 29:130-141(2008) [PubMed] [Europe PMC] [Abstract]