ADP Ribosyltransferase 5 (ART5)

ART5 belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Transcript variants with different 5' UTRs, but encoding the same protein have been found for this gene.

The deduced protein contains a hydrophobic N-terminal peptide, an R-S-EXE motif characteristic of arginine-specific ARTs, and 4 conserved cysteines. Northern blot analysis and RT-PCR detected predominant ART5 expression in mouse heart, skeletal muscle, and testis, and in human testis.