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Fructose-1,6-Bisphosphatase 2 (FBP2)

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Muscle FBPase; D-fructose-1,6-bisphosphate 1-phosphohydrolase 2

Fructose-1,6-Bisphosphatase 2 (FBP2)
CCC G305
HGNC 3607
MGI 95491
RGD 620930
UniProt O00757
Fructose-1,6-bisphosphatase (fru-1,6-P2ase, EC 3.1.3.11) catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate, thus providing a mechanism to permit the reversal of the glycolysis reaction catalyzed by 6-phosphofructo-1-kinase.
Tillmann and Eschrich (1998) stated that human liver and muscle fru-1,6-P2ases appear to be distinct enzymes since they differ significantly in their kinetic properties, and no reduction of fru-1,6-P2ase activity was found in muscle in patients with hereditary liver fru-1,6-P2ase deficiency.The predicted 339-amino acid muscle fru-1,6-P2ase shares 77% protein sequence identity with the liver enzyme. Recombinant enzyme had fru-1,6-P2ase activity in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG305Hu01 Recombinant Fructose-1,6-Bisphosphatase 2 (FBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG305Hu01 Polyclonal Antibody to Fructose-1,6-Bisphosphatase 2 (FBP2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fructose-1,6-Bisphosphatase 2 (FBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fructose-1,6-Bisphosphatase 2 (FBP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG305Mu01 Recombinant Fructose-1,6-Bisphosphatase 2 (FBP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Fructose-1,6-Bisphosphatase 2 (FBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fructose-1,6-Bisphosphatase 2 (FBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fructose-1,6-Bisphosphatase 2 (FBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fructose-1,6-Bisphosphatase 2 (FBP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fructose-1,6-Bisphosphatase 2 (FBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fructose-1,6-Bisphosphatase 2 (FBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fructose-1,6-Bisphosphatase 2 (FBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fructose-1,6-Bisphosphatase 2 (FBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fructose-1,6-Bisphosphatase 2 (FBP2) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of an allelic cDNA for human muscle fructose-1,6-bisphosphatase."Gene 212:295-304(1998) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Immunohistochemical localization of human fructose-1,6-bisphosphatase in subcellular structures of myocytes."Histol. Histopathol. 18:135-142(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The origin of the high sensitivity of muscle fructose 1,6-bisphosphatase towards AMP."FEBS Lett. 579:5577-5581(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Glu 69 is essential for the high sensitivity of muscle fructose-1,6-bisphosphatase inhibition by calcium ions."FEBS Lett. 581:1347-1350(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase."Proteins 72:209-216(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Muscle FBPase is targeted to nucleus by its 203KKKGK207 sequence."Proteins 77:262-267(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of E69Q mutant of human muscle fructose-1,6-bisphosphatase."Acta Crystallogr. D 67:1028-1034(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structures of human muscle fructose-1,6-bisphosphatase: novel quaternary states, enhanced AMP affinity, and allosteric signal transmission pathway."PLoS ONE 8:E71242-E71242(2013) [PubMed] [Europe PMC] [Abstract]