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Absent In Melanoma 2 (AIM2)

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PYHIN4; Interferon-inducible protein AIM2

Absent In Melanoma 2 (AIM2)
CCC G302
HGNC 357
MGI 2686159
PubMed 22555457
RGD 1307283
UniProt O14862
Wiki AIM2
AIM2 plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. AIM2 was expressed as a 39-kD protein following in vitro transcription/translation in rabbit reticulocyte lysate or transfection in a murine epithelial cell line. Cell fractionation showed that AIM2 localized primarily to the cytoplasm of transfected mouse cells.
Chromosome alterations in malignant melanoma most frequently include translocations and deletions on chromosome 1 or 6 . AIM2 encodes a deduced 344-amino acid protein that contains a conserved sequence domain of approximately 200 amino acids shared with interferon-inducible genes as well as a tyrosine kinase phosphorylation site.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG302Hu01 Recombinant Absent In Melanoma 2 (AIM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG302Hu21 Monoclonal Antibody to Absent In Melanoma 2 (AIM2) WB; IHC; ICC; IP.
PAG302Hu01 Polyclonal Antibody to Absent In Melanoma 2 (AIM2) WB; IHC; ICC; IP.
Assay Kits SEG302Hu ELISA Kit for Absent In Melanoma 2 (AIM2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Absent In Melanoma 2 (AIM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Absent In Melanoma 2 (AIM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Absent In Melanoma 2 (AIM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Absent In Melanoma 2 (AIM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Absent In Melanoma 2 (AIM2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Absent In Melanoma 2 (AIM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Absent In Melanoma 2 (AIM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Absent In Melanoma 2 (AIM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Absent In Melanoma 2 (AIM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Absent In Melanoma 2 (AIM2) ELISA Kit Customized Service Offer
  1. "Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma."Oncogene 15:453-457(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2."Biochem. Biophys. Res. Commun. 326:417-424(2005) [PubMed] [Europe PMC] [Abstract]
  6. "AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model."Mol. Cancer Ther. 5:1-7(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers."Genes Chromosomes Cancer 46:1080-1089(2007) [PubMed] [Europe PMC] [Abstract]
  8. "An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome."Nat. Immunol. 10:266-272(2009) [PubMed] [Europe PMC] [Abstract]
  9. "AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA."Nature 458:509-513(2009) [PubMed] [Europe PMC] [Abstract]
  10. "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC."Nature 458:514-518(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes."J. Immunol. 185:1186-1195(2010) [PubMed] [Europe PMC] [Abstract]
  12. "IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes."PLoS ONE 6:E27040-E27040(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Interactome-wide analysis identifies end-binding protein 1 as a crucial component for the speck-like particle formation of activated AIM2 inflammasomes."Mol. Cell. Proteomics 11:1230-1244(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Novel role of PKR in inflammasome activation and HMGB1 release."Nature 488:670-674(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor."Immunity 36:561-571(2012) [PubMed] [Europe PMC] [Abstract]