5'-AMP-activated protein kinase subunit beta-2 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status.
In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPG289Hu01 | Recombinant Protein Kinase, AMP Activated Beta 2 (PRKAb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAG289Hu01 | Polyclonal Antibody to Protein Kinase, AMP Activated Beta 2 (PRKAb2) | WB; IHC; ICC; IP. |
Assay Kits | SEG289Hu | ELISA Kit for Protein Kinase, AMP Activated Beta 2 (PRKAb2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Protein Kinase, AMP Activated Beta 2 (PRKAb2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Protein Kinase, AMP Activated Beta 2 (PRKAb2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Protein Kinase, AMP Activated Beta 2 (PRKAb2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Protein Kinase, AMP Activated Beta 2 (PRKAb2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Protein Kinase, AMP Activated Beta 2 (PRKAb2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Protein Kinase, AMP Activated Beta 2 (PRKAb2) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Protein Kinase, AMP Activated Beta 2 (PRKAb2) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Protein Kinase, AMP Activated Beta 2 (PRKAb2) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Protein Kinase, AMP Activated Beta 2 (PRKAb2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Protein Kinase, AMP Activated Beta 2 (PRKAb2) | ELISA Kit Customized Service Offer |
- "Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle."J. Biol. Chem. 273:12443-12450(1998) [PubMed] [Europe PMC] [Abstract]
- "Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians."Mol. Cell. Probes 16:421-427(2002) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
- "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
- "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
- "Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop."Autophagy 7:696-706(2011) [PubMed] [Europe PMC] [Abstract]
- "AMP-activated protein kinase in metabolic control and insulin signaling."Circ. Res. 100:328-341(2007) [PubMed] [Europe PMC] [Abstract]
- "AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy."Nat. Rev. Mol. Cell Biol. 8:774-785(2007) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Structural basis for AMP binding to mammalian AMP-activated protein kinase."Nature 449:496-500(2007) [PubMed] [Europe PMC] [Abstract]
- "Structure of mammalian AMPK and its regulation by ADP."Nature 472:230-233(2011) [PubMed] [Europe PMC] [Abstract]