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Protein Kinase, AMP Activated Gamma 3 (PRKAg3)

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AMPKG3; 5'-AMP-activated protein kinase subunit gamma-3

Protein Kinase, AMP Activated Gamma 3 (PRKAg3)
CCC G288
HGNC 9387
MGI 1891343
PubMed 10818001
RGD 1308698
UniProt Q9UGI9
Wiki PRKAG3
PRKAg3 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, AMP Activated Gamma 3 (PRKAg3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, AMP Activated Gamma 3 (PRKAg3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, AMP Activated Gamma 3 (PRKAg3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, AMP Activated Gamma 3 (PRKAg3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, AMP Activated Gamma 3 (PRKAg3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG288Mu01 Recombinant Protein Kinase, AMP Activated Gamma 3 (PRKAg3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG288Mu01 Polyclonal Antibody to Protein Kinase, AMP Activated Gamma 3 (PRKAg3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Kinase, AMP Activated Gamma 3 (PRKAg3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, AMP Activated Gamma 3 (PRKAg3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, AMP Activated Gamma 3 (PRKAg3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, AMP Activated Gamma 3 (PRKAg3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, AMP Activated Gamma 3 (PRKAg3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, AMP Activated Gamma 3 (PRKAg3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, AMP Activated Gamma 3 (PRKAg3) ELISA Kit Customized Service Offer
  1. "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding."Biochem. J. 346:659-669(2000) [PubMed] [Europe PMC] [Abstract]
  2. "A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle."Science 288:1248-1251(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations."J. Clin. Invest. 113:274-284(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit."EMBO J. 26:806-815(2007) [PubMed] [Europe PMC] [Abstract]
  6. "AMP-activated protein kinase in metabolic control and insulin signaling."Circ. Res. 100:328-341(2007) [PubMed] [Europe PMC] [Abstract]
  7. "AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy."Nat. Rev. Mol. Cell Biol. 8:774-785(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop."Autophagy 7:696-706(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscle."PLoS ONE 2:E903-E903(2007) [PubMed] [Europe PMC] [Abstract]