≡

Proteasome 26S Subunit, Non ATPase 4 (PSMD4)

[Edit]

ASF; AF-1; AF; MCB1; Rpn10; S5A; pUB-R5; Antisecretory factor 1; Multiubiquitin chain-binding protein; 26S proteasome regulatory subunit RPN10

Proteasome 26S Subunit, Non ATPase 4 (PSMD4)
CCC G280
HGNC 9561
MGI 1201670
PubMed 21628408
RGD 621109
UniProt P55036
Wiki PSMD4
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSMD4 encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG280Hu01 Recombinant Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG280Hu01 Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 4 (PSMD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, Non ATPase 4 (PSMD4) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of a pituitary gland protein modulating intestinal fluid secretion."J. Biol. Chem. 270:20615-20620(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and expression of a multiubiquitin chain binding subunit of the human 26S protease."FEBS Lett. 381:143-148(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes."EMBO J. 19:4144-4153(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Purification and characterization of the antisecretory factor: a protein in the central nervous system and in the gut which inhibits intestinal hypersecretion induced by cholera toxin."Biochim. Biophys. Acta 883:138-144(1986) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a."J. Biol. Chem. 273:5461-5467(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1."J. Biol. Chem. 276:46655-46660(2001) [PubMed] [Europe PMC] [Abstract]
  9. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up."J. Biol. Chem. 279:42290-42301(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation."Mol. Cell. Biol. 24:8055-8068(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
  13. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes."Mol. Cell. Biol. 32:3095-3106(2012) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Structural determinants for the binding of ubiquitin-like domains to the proteasome."EMBO J. 22:4634-4645(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B."J. Biol. Chem. 279:4760-4767(2004) [PubMed] [Europe PMC] [Abstract]