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Proteasome 26S Subunit, Non ATPase 2 (PSMD2)

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P97; S2; TRAP2; Rpn1; Tumor necrosis factor type 1 receptor-associated protein 2; 26S proteasome regulatory subunit RPN1; 26S proteasome subunit p97

Proteasome 26S Subunit, Non ATPase 2 (PSMD2)
CCC G279
HGNC 9559
MGI 1096584
PubMed 17949559
RGD 1305752
UniProt Q13200
Wiki PSMD2
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.
PSMD2 encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG279Hu01 Recombinant Proteasome 26S Subunit, Non ATPase 2 (PSMD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG279Hu01 Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome 26S Subunit, Non ATPase 2 (PSMD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome 26S Subunit, Non ATPase 2 (PSMD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 2 (PSMD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, Non ATPase 2 (PSMD2) ELISA Kit Customized Service Offer
  1. "cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11."Eur. J. Biochem. 239:912-921(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease."J. Immunol. 158:4252-4259(1997) [PubMed] [Europe PMC] [Abstract]
  6. "A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its 'death domain'."FEBS Lett. 367:39-44(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]