≡

Proteasome 26S Subunit, ATPase 3 (PSMC3)

[Edit]

TBP1; Tat-binding protein 1; Proteasome subunit P50; 26S proteasome AAA-ATPase subunit RPT5

Proteasome 26S Subunit, ATPase 3 (PSMC3)
CCC G278
HGNC 9549
MGI 1098754
PubMed 9048938
RGD 61905
UniProt P17980
Wiki PSMC3
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.
PSMC3 encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG278Hu01 Recombinant Proteasome 26S Subunit, ATPase 3 (PSMC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG278Hu01 Polyclonal Antibody to Proteasome 26S Subunit, ATPase 3 (PSMC3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, ATPase 3 (PSMC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, ATPase 3 (PSMC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome 26S Subunit, ATPase 3 (PSMC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome 26S Subunit, ATPase 3 (PSMC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome 26S Subunit, ATPase 3 (PSMC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, ATPase 3 (PSMC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, ATPase 3 (PSMC3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome 26S Subunit, ATPase 3 (PSMC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome 26S Subunit, ATPase 3 (PSMC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome 26S Subunit, ATPase 3 (PSMC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, ATPase 3 (PSMC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, ATPase 3 (PSMC3) ELISA Kit Customized Service Offer
  1. "The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes."Proc. Natl. Acad. Sci. U.S.A. 90:138-142(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator."Science 248:1650-1653(1990) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (DEC-2008) to UniProtKB
  6. "Identification, purification, and characterization of a PA700-dependent activator of the proteasome."J. Biol. Chem. 271:3112-3118(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases."Mol. Cell. Biol. 25:3842-3853(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation."Nucleic Acids Res. 35:E109-E109(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]