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Proteasome Subunit Beta Type 5 (PSMb5)

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LMPX; MB1; Macropain epsilon chain; Multicatalytic endopeptidase complex epsilon chain; Proteasome subunit MB1

Proteasome Subunit Beta Type 5 (PSMb5)
CCC G270
HGNC 9542
MGI 1194513
PubMed 16723119
RGD 61879
UniProt P28074
Wiki PSMB5
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMB5 encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Subunit Beta Type 5 (PSMb5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Subunit Beta Type 5 (PSMb5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Subunit Beta Type 5 (PSMb5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Subunit Beta Type 5 (PSMb5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Beta Type 5 (PSMb5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Subunit Beta Type 5 (PSMb5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Subunit Beta Type 5 (PSMb5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Subunit Beta Type 5 (PSMb5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Subunit Beta Type 5 (PSMb5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Beta Type 5 (PSMb5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Subunit Beta Type 5 (PSMb5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Subunit Beta Type 5 (PSMb5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Subunit Beta Type 5 (PSMb5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Subunit Beta Type 5 (PSMb5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Beta Type 5 (PSMb5) ELISA Kit Customized Service Offer
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  19. "Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line."J. Pharmacol. Exp. Ther. 326:423-431(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line."Exp. Hematol. 37:831-837(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane."J. Nutr. Biochem. 20:195-201(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]