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Chromobox Homolog 4 (CBX4)

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PC2; hPC2; NBP16; NS5ATP1-Binding Protein 16; E3 SUMO-protein ligase CBX4; Polycomb 2 homolog

Chromobox Homolog 4 (CBX4)
CCC G267
HGNC 1554
MGI 1195985
PubMed 21885019
RGD 1587243
UniProt O00257
'Polycomb' (Pc) and other members of the Drosophila Polycomb group gene family are part of a cellular memory system that is responsible for the inheritance of gene activity by progeny cells. Pc shares a homologous domain known as the chromodomain with the Drosophila heterochromatin-binding protein, HP1. To isolate human Pc homologs, Satijn et al. (1997) screened a fetal brain cDNA library with a probe containing the nonchromodomain portion of a Xenopus Pc homolog (XPc). They recovered a cDNA encoding a predicted 558-amino acid protein that they designated human Pc2. Human Pc2 and XPc share 48% protein sequence identity. Northern blot analysis revealed that human Pc2 is expressed as a 2.8-kb transcript in all tissues tested with almost equal abundance.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromobox Homolog 4 (CBX4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromobox Homolog 4 (CBX4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromobox Homolog 4 (CBX4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromobox Homolog 4 (CBX4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromobox Homolog 4 (CBX4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromobox Homolog 4 (CBX4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromobox Homolog 4 (CBX4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromobox Homolog 4 (CBX4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromobox Homolog 4 (CBX4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromobox Homolog 4 (CBX4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromobox Homolog 4 (CBX4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromobox Homolog 4 (CBX4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromobox Homolog 4 (CBX4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromobox Homolog 4 (CBX4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromobox Homolog 4 (CBX4) ELISA Kit Customized Service Offer
  1. "Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis."Mol. Cell. Biol. 17:6076-6086(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment."PLoS Genet. 5:E1000397-E1000397(2009) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor."Mol. Cell. Biol. 17:4105-4113(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins."Mol. Cell. Biol. 22:5539-5553(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans."Mol. Cell. Biol. 22:6070-6078(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The polycomb protein Pc2 is a SUMO E3."Cell 113:127-137(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Multiple activities contribute to Pc2 E3 function."EMBO J. 24:108-119(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin."J. Biol. Chem. 280:35477-35489(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2."Mol. Cell 24:77-89(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus."PLoS ONE 4:E6380-E6380(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling."J. Biol. Chem. 287:17517-17529(2012) [PubMed] [Europe PMC] [Abstract]
  17. "DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation."J. Biol. Chem. 287:30789-30799(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Solution NMR structure of the chromo domain of the chromobox protein homolog 4."Submitted (FEB-2009) to the PDB data bank
  20. "Crystal structure of human chromobox homolog 4 (cbx4)."Submitted (SEP-2009) to the PDB data bank