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Proteasome Subunit Alpha Type 7 (PSMa7)

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C6; HSPC; RC6-1; XAPC7

Proteasome Subunit Alpha Type 7 (PSMa7)
CCC G262
HGNC 9536
MGI 1347070
PubMed 18202793
RGD 61851
UniProt O14818
Wiki PSMA7
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. PSMA7 has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication.
This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG262Hu01 Recombinant Proteasome Subunit Alpha Type 7 (PSMa7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG262Hu21 Monoclonal Antibody to Proteasome Subunit Alpha Type 7 (PSMa7) WB; IHC; ICC; IP.
PAG262Hu01 Polyclonal Antibody to Proteasome Subunit Alpha Type 7 (PSMa7) WB; IHC; ICC; IP.
Assay Kits SEG262Hu ELISA Kit for Proteasome Subunit Alpha Type 7 (PSMa7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Subunit Alpha Type 7 (PSMa7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Subunit Alpha Type 7 (PSMa7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Subunit Alpha Type 7 (PSMa7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Subunit Alpha Type 7 (PSMa7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Alpha Type 7 (PSMa7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Subunit Alpha Type 7 (PSMa7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Subunit Alpha Type 7 (PSMa7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Subunit Alpha Type 7 (PSMa7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Subunit Alpha Type 7 (PSMa7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Alpha Type 7 (PSMa7) ELISA Kit Customized Service Offer
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  6. , Submitted (MAR-2007) to UniProtKB
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  8. "Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7."FEBS Lett. 498:62-66(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation."Mol. Cell. Biol. 21:8357-8364(2001) [PubMed] [Europe PMC] [Abstract]
  10. "C-SPACE (cleavage-specific amplification of cDNA ends): a novel method of ribozyme-mediated gene identification."Nucleic Acids Res. 29:E94-E94(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Proteasome activity is required for androgen receptor transcriptional activity via regulation of androgen receptor nuclear translocation and interaction with coregulators in prostate cancer cells."J. Biol. Chem. 277:36570-36576(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits."FEBS Lett. 553:200-204(2003) [PubMed] [Europe PMC] [Abstract]
  13. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  14. "The proteasome alpha-subunit XAPC7 interacts specifically with Rab7 and late endosomes."J. Biol. Chem. 279:21334-21342(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Parkin interacts with the proteasome subunit alpha4."FEBS Lett. 579:3913-3919(2005) [PubMed] [Europe PMC] [Abstract]
  16. "A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes."Nature 437:1381-1385(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation."Mol. Cell 22:317-327(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
  19. "The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer."Oncol. Rep. 19:441-446(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome."Exp. Cell Res. 315:1850-1859(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Negative regulation of MAVS-mediated innate immune response by PSMA7."J. Immunol. 183:4241-4248(2009) [PubMed] [Europe PMC] [Abstract]
  22. "PSMA7, a potential biomarker of diseases."Protein Pept. Lett. 16:486-489(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]