Proteasome Subunit Alpha Type 4 (PSMa4)

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HC9; PSC9; Macropain subunit C9; Multicatalytic endopeptidase complex subunit C9; Proteasome component C9; Proteasome subunit L

Proteasome Subunit Alpha Type 4 (PSMa4)
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
PSMA4encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG259Hu01 Recombinant Proteasome Subunit Alpha Type 4 (PSMa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG259Hu01 Polyclonal Antibody to Proteasome Subunit Alpha Type 4 (PSMa4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proteasome Subunit Alpha Type 4 (PSMa4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Alpha Type 4 (PSMa4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Subunit Alpha Type 4 (PSMa4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Subunit Alpha Type 4 (PSMa4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Subunit Alpha Type 4 (PSMa4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Subunit Alpha Type 4 (PSMa4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Alpha Type 4 (PSMa4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Subunit Alpha Type 4 (PSMa4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Subunit Alpha Type 4 (PSMa4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Subunit Alpha Type 4 (PSMa4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Subunit Alpha Type 4 (PSMa4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Alpha Type 4 (PSMa4) ELISA Kit Customized Service Offer
  1. "Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes)."Biochim. Biophys. Acta 1089:95-102(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human proteasome subunits from 2-dimensional gels identified by partial sequencing."Biochem. Biophys. Res. Commun. 205:1785-1789(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome."Nature 381:328-331(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Gene expression induced by BO-653, probucol and BHQ in human endothelial cells."J. Atheroscler. Thromb. 7:223-230(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]