≡

Proteasome Subunit Alpha Type 3 (PSMa3)

[Edit]

HC8; PSC3; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8

Proteasome Subunit Alpha Type 3 (PSMa3)
CCC G258
HGNC 9532
MGI 104883
PubMed 22079093
RGD 61844
UniProt P25788
Wiki PSMA3
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
PSMA3encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Subunit Alpha Type 3 (PSMa3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Subunit Alpha Type 3 (PSMa3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Subunit Alpha Type 3 (PSMa3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Subunit Alpha Type 3 (PSMa3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Alpha Type 3 (PSMa3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Subunit Alpha Type 3 (PSMa3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Subunit Alpha Type 3 (PSMa3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Subunit Alpha Type 3 (PSMa3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Subunit Alpha Type 3 (PSMa3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Alpha Type 3 (PSMa3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Subunit Alpha Type 3 (PSMa3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Subunit Alpha Type 3 (PSMa3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Subunit Alpha Type 3 (PSMa3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Subunit Alpha Type 3 (PSMa3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Alpha Type 3 (PSMa3) ELISA Kit Customized Service Offer
  1. "Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes)."Biochim. Biophys. Acta 1089:95-102(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human proteasome subunits from 2-dimensional gels identified by partial sequencing."Biochem. Biophys. Res. Commun. 205:1785-1789(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Gene expression induced by BO-653, probucol and BHQ in human endothelial cells."J. Atheroscler. Thromb. 7:223-230(2000) [PubMed] [Europe PMC] [Abstract]
  6. "A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome."EMBO J. 20:2367-2375(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Mapping and structural dissection of human 20 s proteasome using proteomic approaches."Mol. Cell. Proteomics 1:567-578(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Analysis of gene expression during maturation of immature dendritic cells derived from peripheral blood monocytes."Scand. J. Immunol. 56:593-601(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits."FEBS Lett. 553:200-204(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Human Aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner."Mol. Cell. Biochem. 254:157-162(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Epstein-Barr virus EBNA3 proteins bind to the C8/alpha7 subunit of the 20S proteasome and are degraded by 20S proteasomes in vitro, but are very stable in latently infected B cells."J. Gen. Virol. 86:1269-1277(2005) [PubMed] [Europe PMC] [Abstract]
  12. "MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein."Mol. Cell 20:699-708(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Chemical structure-dependent gene expression of proteasome subunits via regulation of the antioxidant response element."Free Radic. Res. 40:21-30(2006) [PubMed] [Europe PMC] [Abstract]
  16. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes."Prostaglandins Other Lipid Mediat. 83:237-249(2007) [PubMed] [Europe PMC] [Abstract]
  20. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  21. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Ubiquitin-independent degradation of hepatitis C virus F protein."J. Virol. 83:612-621(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  29. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  30. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  31. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  32. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]