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N-Acetylglucosamine Kinase (NAGK)

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GNK; N-acetyl-D-glucosamine kinase

N-Acetylglucosamine Kinase (NAGK)
CCC G243
HGNC 17174
MGI 1860418
PubMed 10824116
RGD 1305057
UniProt Q9UJ70
Wiki NAGK
N-acetylglucosamine kinase (NAGK; EC 2.7.1.59) converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. NAGK belongs to the group of N-acetylhexosamine kinases and is a prominent salvage enzyme of amino sugar metabolism in mammals.
Using the mouse Nagk sequence to search the human EST database, Hinderlich et al. (2000) obtained a complete cDNA encoding NAGK. The predicted 344-amino acid NAGK protein contains the 5 sequence motifs necessary for the binding of ATP by sugar kinases. NAGK shares 91.6% amino acid similarity with mouse Nagk.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acetylglucosamine Kinase (NAGK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acetylglucosamine Kinase (NAGK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acetylglucosamine Kinase (NAGK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acetylglucosamine Kinase (NAGK) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acetylglucosamine Kinase (NAGK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acetylglucosamine Kinase (NAGK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acetylglucosamine Kinase (NAGK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acetylglucosamine Kinase (NAGK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acetylglucosamine Kinase (NAGK) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acetylglucosamine Kinase (NAGK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acetylglucosamine Kinase (NAGK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acetylglucosamine Kinase (NAGK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acetylglucosamine Kinase (NAGK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acetylglucosamine Kinase (NAGK) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acetylglucosamine Kinase (NAGK) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of murine and human N-acetylglucosamine kinase."Eur. J. Biochem. 267:3301-3308(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (MAR-2007) to UniProtKB
  7. "Identification of the phosphotyrosine proteome from thrombin activated platelets."Proteomics 2:642-648(2002) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid."J. Biol. Chem. 287:28865-28881(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structures of human N-acetylglucosamine kinase in two complexes with N-acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation."J. Mol. Biol. 364:388-399(2006) [PubMed] [Europe PMC] [Abstract]