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Forkhead Box Protein C2 (FOXC2)

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FOX-C2 ; FKHL14; MFH-1; Mesenchyme Forkhead 1; Mesenchyme fork head protein 1; Transcription factor FKH-14

Forkhead Box Protein C2 (FOXC2)
CCC G217
HGNC 3801
MGI 1347481
PubMed 23378344
UniProt Q99958
Wiki FOXC2
FOXC2 is also involved in cancer metastases. Particularly, expression of FOXC2 is induced when epithelial cells undergo an epithelial-mesenchymal transition (EMT) and become mesenchymal looking cells. EMT can be induced by a number of genes including Snail, Twist, Goosecoid, and TGF-beta 1. Suppression of FOXC2 expression using shRNA in a highly metastatic breast cancer model blocks their metastatic ability.
The nature of these Foxc2-generated responses was consistent with protection against obesity and related symptoms, such as diet-induced insulin resistance. Furthermore, in wildtype mice, Foxc2 mRNA levels were upregulated by high-fat diet, whereas mice with targeted disruption of 1 Foxc2 allele had a decreased interscapular BAT cell mass.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein C2 (FOXC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein C2 (FOXC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein C2 (FOXC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein C2 (FOXC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein C2 (FOXC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein C2 (FOXC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein C2 (FOXC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein C2 (FOXC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein C2 (FOXC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein C2 (FOXC2) ELISA Kit Customized Service Offer
  1. "Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures."Genomics 41:489-492(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome."Am. J. Hum. Genet. 67:1382-1388(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Truncating mutations in FOXC2 cause multiple lymphedema syndromes."Hum. Mol. Genet. 10:1185-1189(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphorylation regulates FOXC2-mediated transcription in lymphatic endothelial cells."Mol. Cell. Biol. 33:3749-3761(2013) [PubMed] [Europe PMC] [Abstract]
  13. "Solution structure and dynamics of the DNA-binding domain of the adipocyte-transcription factor FREAC-11."J. Mol. Biol. 296:351-359(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Analysis of lymphoedema-distichiasis families for FOXC2 mutations reveals small insertions and deletions throughout the gene."Hum. Genet. 108:546-551(2001) [PubMed] [Europe PMC] [Abstract]