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Cytochrome P450 3A5 (CYP3A5)

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CP35; P450PCN3; PCN3; Cytochrome P450,Subfamily IIIA(Niphedipine Oxidase),Polypeptide 5; Cytochrome P450 HLp2

Cytochrome P450 3A5 (CYP3A5)
CCC G206
HGNC 2638
MGI 88609
RGD 708392
UniProt P20815
CYP3A5 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 3A5 (CYP3A5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 3A5 (CYP3A5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 3A5 (CYP3A5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 3A5 (CYP3A5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 3A5 (CYP3A5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 3A5 (CYP3A5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 3A5 (CYP3A5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 3A5 (CYP3A5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 3A5 (CYP3A5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 3A5 (CYP3A5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 3A5 (CYP3A5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 3A5 (CYP3A5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 3A5 (CYP3A5) Polyclonal Antibody Customized Service Offer
Assay Kits SEG206Ra ELISA Kit for Cytochrome P450 3A5 (CYP3A5) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine."J. Biol. Chem. 264:10388-10395(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver."Arch. Biochem. Biophys. 274:355-365(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene."Pharmacogenetics 11:111-121(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells."Mol. Pharmacol. 49:63-72(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7."Biochem. Biophys. Res. Commun. 205:1741-1747(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Intergenic mRNA molecules resulting from trans-splicing."J. Biol. Chem. 277:5882-5890(2002) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?"Biochem. Biophys. Res. Commun. 221:466-470(1996) [PubMed] [Europe PMC] [Abstract]
  13. "Genetic polymorphism of cytochrome P450 3A5 in Chinese."Drug Metab. Dispos. 29:1205-1209(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups."Pharmacogenetics 13:461-472(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]