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K-Acetyltransferase 5 (KAT5)

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HTATIP; ESA1; HTATIP1; PLIP; TIP; TIP60; cPLA2; HIV-1 Tat Interacting Protein,60kDa; 60 kDa Tat-interactive protein; Lysine acetyltransferase 5; Histone acetyltransferase HTATIP

K-Acetyltransferase 5 (KAT5)
CCC G190
HGNC 5275
MGI 1932051
PubMed 23708966
RGD 621061
UniProt Q92993
Wiki KAT5
KAT5 belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.The deduced 383-amino acid protein has a calculated molecular mass of 44 kD. TIP60 shares significant similarity with yeast Sas2, which is thought to function in gene silencing. Northern blot analysis detected a 1.9-kb transcript in human monocyte, T-lymphocyte, and HeLa cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG190Hu01 Recombinant K-Acetyltransferase 5 (KAT5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to K-Acetyltransferase 5 (KAT5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to K-Acetyltransferase 5 (KAT5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for K-Acetyltransferase 5 (KAT5) CLIA Kit Customized Service Offer
n/a ELISA Kit for K-Acetyltransferase 5 (KAT5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant K-Acetyltransferase 5 (KAT5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to K-Acetyltransferase 5 (KAT5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to K-Acetyltransferase 5 (KAT5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for K-Acetyltransferase 5 (KAT5) CLIA Kit Customized Service Offer
n/a ELISA Kit for K-Acetyltransferase 5 (KAT5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant K-Acetyltransferase 5 (KAT5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to K-Acetyltransferase 5 (KAT5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to K-Acetyltransferase 5 (KAT5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for K-Acetyltransferase 5 (KAT5) CLIA Kit Customized Service Offer
n/a ELISA Kit for K-Acetyltransferase 5 (KAT5) ELISA Kit Customized Service Offer
  1. "Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator."Virology 216:357-366(1996) [PubMed] [Europe PMC] [Abstract]
  2. "PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production."Mol. Cell. Biol. 21:4470-4481(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a larger form of the histone acetyl transferase Tip60."Gene 310:161-168(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex."J. Biol. Chem. 278:42733-42736(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Tip60 acetylates six lysines of a specific class in core histones in vitro."Genes Cells 3:789-800(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis."Cell 102:463-473(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling."J. Biol. Chem. 276:16597-16600(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation."EMBO J. 21:1704-1712(2002) [PubMed] [Europe PMC] [Abstract]
  12. "MYC recruits the TIP60 histone acetyltransferase complex to chromatin."EMBO Rep. 4:575-580(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Tip60 acetyltransferase activity is controlled by phosphorylation."J. Biol. Chem. 278:4713-4718(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Tip60 is a co-repressor for STAT3."J. Biol. Chem. 278:11197-11204(2003) [PubMed] [Europe PMC] [Abstract]
  15. "The highly conserved and multifunctional NuA4 HAT complex."Curr. Opin. Genet. Dev. 14:147-154(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Role of the histone acetyl transferase Tip60 in the p53 pathway."J. Biol. Chem. 279:44825-44833(2004) [PubMed] [Europe PMC] [Abstract]
  17. "von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity."J. Biol. Chem. 279:56032-56041(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans."Mol. Cell. Biol. 24:1884-1896(2004) [PubMed] [Europe PMC] [Abstract]
  19. "E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1."Mol. Cell. Biol. 24:4546-4556(2004) [PubMed] [Europe PMC] [Abstract]
  20. "A large-scale RNAi screen in human cells identifies new components of the p53 pathway."Nature 428:431-437(2004) [PubMed] [Europe PMC] [Abstract]
  21. "HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses."EMBO J. 24:2634-2645(2005) [PubMed] [Europe PMC] [Abstract]
  22. "A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM."Proc. Natl. Acad. Sci. U.S.A. 102:13182-13187(2005) [PubMed] [Europe PMC] [Abstract]
  23. "The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity."J. Biol. Chem. 281:27356-27366(2006) [PubMed] [Europe PMC] [Abstract]
  24. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
  25. "FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression."Proc. Natl. Acad. Sci. U.S.A. 104:4571-4576(2007) [PubMed] [Europe PMC] [Abstract]
  26. "The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter."Biochim. Biophys. Acta 1783:224-236(2008) [PubMed] [Europe PMC] [Abstract]
  27. "TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells."Cancer Res. 68:3486-3494(2008) [PubMed] [Europe PMC] [Abstract]
  28. "Regulation of TIP60 by ATF2 modulates ATM activation."J. Biol. Chem. 283:17605-17614(2008) [PubMed] [Europe PMC] [Abstract]
  29. "Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response." Oncogene 27:931-941(2008) [PubMed] [Europe PMC] [Abstract]
  30. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  31. "TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells."Biochim. Biophys. Acta 1793:1828-1836(2009) [PubMed] [Europe PMC] [Abstract]
  32. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  33. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  34. "Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress."Nucleic Acids Res. 42:11447-11461(2014) [PubMed] [Europe PMC] [Abstract]
  35. "ANP32E is a histone chaperone that removes H2A.Z from chromatin."Nature 505:648-653(2014) [PubMed] [Europe PMC] [Abstract]
  36. "The crystal structure of acetyltransferase domain of human HIV-1 TAT interacting protein in complex with acetylcoenzyme A."Submitted (FEB-2009) to the PDB data bank
  37. "Solution structure of RUH-073, a pseudo chromo domain from human cDNA."Submitted (FEB-2009) to the PDB data bank