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Dedicator Of Cytokinesis 2 (DOCK2)

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Dedicator Of Cytokinesis 2 (DOCK2)
CCC G182
HGNC 2988
MGI 2149010
PubMed 11394736
RGD 1564189
UniProt Q92608
Wiki Dock2
Dock2 is part of a large class of proteins (GEFs) which contibrute to cellular signalling events by activating small G proteins. In their resting state G proteins are bound to Guanosine diphosphate (GDP) and their activation requires the dissociation of GDP and binding of guanosine triphosphate (GTP). GEFs activate G proteins by promoting this nucleotide exchange.
Dock2 and other DOCK family proteins differ from other GEFs in that they do not possess the canonical structure of tandem DH-PH domains known to elicit nucleotide exchange. Instead they possess a DHR2 domain which mediates Rac activation by stabilising it in its nucleotide-free state. They also contain a DHR1 domain which binds phospholipids and is required for the interaction between Dock2 and the plasma membrane.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG182Hu01 Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG182Hu01 Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dedicator Of Cytokinesis 2 (DOCK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dedicator Of Cytokinesis 2 (DOCK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dedicator Of Cytokinesis 2 (DOCK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dedicator Of Cytokinesis 2 (DOCK2) ELISA Kit Customized Service Offer
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  4. "DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines."Blood 100:3968-3974(2002) [PubMed] [Europe PMC] [Abstract]
  5. "DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription."Biochem. Biophys. Res. Commun. 296:716-720(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract]
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  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "The solution structure of human DOCK2 SH3 domain - ELMO1 peptide chimera complex."Submitted (OCT-2010) to the PDB data bank
  15. "Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors."J. Biol. Chem. 286:25341-25351(2011) [PubMed] [Europe PMC] [Abstract]