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Disabled Homolog 2 (DAB2)

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DOC2; mitogen-responsive phosphoprotein; Differentially-expressed protein 2

Disabled Homolog 2 (DAB2)
CCC G170
HGNC 2662
MGI 109175
PubMed 22265793
RGD 621007
UniProt P98082
Wiki DAB2
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis.
This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG170Hu01 Recombinant Disabled Homolog 2 (DAB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Disabled Homolog 2 (DAB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Disabled Homolog 2 (DAB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Disabled Homolog 2 (DAB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Disabled Homolog 2 (DAB2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Disabled Homolog 2 (DAB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Disabled Homolog 2 (DAB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Disabled Homolog 2 (DAB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Disabled Homolog 2 (DAB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Disabled Homolog 2 (DAB2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Disabled Homolog 2 (DAB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Disabled Homolog 2 (DAB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Disabled Homolog 2 (DAB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Disabled Homolog 2 (DAB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Disabled Homolog 2 (DAB2) ELISA Kit Customized Service Offer
  1. "Sequence, genomic structure, and chromosomal assignment of human DOC-2."Genomics 33:207-213(1996) [PubMed] [Europe PMC] [Abstract]
  2. "DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer."Oncogene 16:2381-2387(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Disabled-2 inactivation is an early step in ovarian tumorigenicity."Oncogene 18:3104-3113(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2)."Genomics 70:381-386(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular cloning of differentially expressed genes in human epithelial ovarian cancer."Gynecol. Oncol. 52:247-252(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin."Biochem. J. 347:613-621(2000) [PubMed] [Europe PMC] [Abstract]
  9. "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway."EMBO J. 20:2789-2801(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton."Traffic 3:331-341(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)."EMBO J. 22:3084-3094(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Dab2 links CIN85 with clathrin-mediated receptor internalization."FEBS Lett. 554:81-87(2003) [PubMed] [Europe PMC] [Abstract]
  13. "The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin."Biochimie 86:179-182(2004) [PubMed] [Europe PMC] [Abstract]
  14. "The role of DOC-2/DAB2 in modulating androgen receptor-mediated cell growth via the nongenomic c-Src-mediated pathway in normal prostatic epithelium and cancer."Cancer Res. 65:9906-9913(2005) [PubMed] [Europe PMC] [Abstract]
  15. "The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH."J. Cell Sci. 119:4235-4246(2006) [PubMed] [Europe PMC] [Abstract]
  16. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Focal adhesion disassembly requires clathrin-dependent endocytosis of integrins."FEBS Lett. 583:1337-1343(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis."J. Biol. Chem. 286:5392-5403(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator."Biochem. J. 441:633-643(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Disabled-2 (Dab2) inhibits Wnt/beta-catenin signalling by binding LRP6 and promoting its internalization through clathrin."EMBO J. 31:2336-2349(2012) [PubMed] [Europe PMC] [Abstract]
  25. "FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis."Mol. Biol. Cell 23:1330-1342(2012) [PubMed] [Europe PMC] [Abstract]
  26. "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."Nat. Cell Biol. 14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
  27. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]