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Small Ubiquitin Related Modifier Protein 2 (SUMO2)

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HSMT3; SMT3B; SMT3H2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3B

Small Ubiquitin Related Modifier Protein 2 (SUMO2)
CCC G152
HGNC 11125
MGI 2158813
PubMed 8630065
UniProt P61956
Wiki SUMO2
Small ubiquitin-related modifier 2 is a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system.
However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG152Hu01 Recombinant Small Ubiquitin Related Modifier Protein 2 (SUMO2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG152Hu01 Polyclonal Antibody to Small Ubiquitin Related Modifier Protein 2 (SUMO2) WB; IHC; ICC; IP.
MAG152Hu21 Monoclonal Antibody to Small Ubiquitin Related Modifier Protein 2 (SUMO2) WB; IHC; ICC; IP.
Assay Kits SEG152Hu ELISA Kit for Small Ubiquitin Related Modifier Protein 2 (SUMO2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Ubiquitin Related Modifier Protein 2 (SUMO2) Recombinant Protein Customized Service Offer
Antibodies PAG152Mu01 Polyclonal Antibody to Small Ubiquitin Related Modifier Protein 2 (SUMO2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Small Ubiquitin Related Modifier Protein 2 (SUMO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Ubiquitin Related Modifier Protein 2 (SUMO2) ELISA Kit Customized Service Offer
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  10. "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation."Biochemistry 42:9959-9969(2003) [PubMed] [Europe PMC] [Abstract]
  11. "A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex."Structure 12:1519-1531(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1."Biochem. J. 386:325-330(2005) [PubMed] [Europe PMC] [Abstract]
  13. "NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression."Proc. Natl. Acad. Sci. U.S.A. 103:5308-5313(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25."Mol. Cell 30:610-619(2008) [PubMed] [Europe PMC] [Abstract]
  15. "RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation."Nat. Cell Biol. 10:538-546(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."J. Biol. Chem. 285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."J. Biol. Chem. 286:43793-43808(2011) [PubMed] [Europe PMC] [Abstract]
  20. "The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA."Cancer Res. 72:2275-2284(2012) [PubMed] [Europe PMC] [Abstract]
  21. "PolySUMO-binding proteins identified through a string search."J. Biol. Chem. 287:42071-42083(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Ube2W conjugates ubiquitin to alpha-amino groups of protein N-termini."Biochem. J. 453:137-145(2013) [PubMed] [Europe PMC] [Abstract]
  23. "A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage."Genes Dev. 27:2227-2232(2013) [PubMed] [Europe PMC] [Abstract]
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  25. "Solution structure of human SUMO-2 (SMT3B), a ubiquitin-like protein."Submitted (AUG-2005) to the PDB data bank
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  27. "Solution structure of human small ubiquitin-like modifier protein isoform 2 (SUMO-2)."Submitted (OCT-2006) to the PDB data bank