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Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2)

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MSE1; GluRS; Glutamate tRNA Ligase 2,Mitochondrial; Glutamyl-tRNA synthetase

Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2)
CCC G140
HGNC 29419
MGI 1914667
RGD 1596451
UniProt Q5JPH6
By sequencing clones obtained from a size-fractionated fetal brain cDNA library, Nagase et al. (2001) cloned EARS2. The transcript has repetitive elements in its 3-prime end, and the deduced protein contains 519 amino acids. RT-PCR ELISA detected robust EARS2 expression in all adult and fetal tissues and specific adult brain regions examined.
By searching databases for aminoacyl-tRNA synthetases containing a mitochondrial targeting sequence, Bonnefond et al. (2005) identified EARS2, which the called mitochondrial GLURS. The deduced 523-amino acid protein has an N-terminal mitochondrial targeting signal with a predicted cleavage site after residue 25. EARS2 has characteristics of a class I aminoacyl-tRNA synthetase, including a classical Rossmann fold.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG140Hu01 Recombinant Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG140Mu01 Recombinant Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutamyl tRNA Synthetase 2, Mitochondrial (EARS2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS."Biochemistry 44:4805-4816(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Leukoencephalopathy with thalamus and brainstem involvement and high lactate 'LTBL' caused by EARS2 mutations."Brain 135:1387-1394(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Multisystem fatal infantile disease caused by a novel homozygous EARS2 mutation."Brain 136:E228-E228(2013) [PubMed] [Europe PMC] [Abstract]