≡

Leucyl tRNA Synthetase 2, Mitochondrial (LARS2)

[Edit]

LEURS; Leucine tRNA Ligase 2,Mitocondrial; Leucyl-tRNA synthetase

Leucyl tRNA Synthetase 2, Mitochondrial (LARS2)
CCC G133
HGNC 17095
MGI 2142973
PubMed 19847392
RGD 1308429
UniProt Q15031
Wiki LARS2
LARS2 encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.
By searching databases for aminoacyl-tRNA synthetases containing a mitochondrial targeting sequence, Bonnefond et al. (2005) identified LARS2, which the called mitochondrial LEURS. The deduced 903-amino acid protein has an N-terminal mitochondrial targeting signal that is cleaved after residue 39. LARS2 has characteristics of a class I aminoacyl-tRNA synthetase, including a classical Rossmann fold.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG133Hu01 Recombinant Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG133Mu01 Recombinant Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucyl tRNA Synthetase 2, Mitochondrial (LARS2) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  4. "Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes."Mol. Cell. Biol. 30:2147-2154(2010) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase, lead to premature ovarian failure and hearing loss in Perrault syndrome."Am. J. Hum. Genet. 92:614-620(2013) [PubMed] [Europe PMC] [Abstract]