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Microtubule Associated Protein 1S (MAP1S)

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BPY2IP1; MAP8; VCY2IP-1; VCY2IP1; VCY2 Interacting Protein 1; BPY2 Interacting Protein 1; Microtubule-associated protein 8; Variable charge Y chromosome 2-interacting protein 1

Microtubule Associated Protein 1S (MAP1S)
CCC G125
HGNC 15715
MGI 2443304
PubMed 11827465
RGD 1308266
UniProt Q66K74
Wiki MAP1S
Using the SEC1 homology domain of LRPPRC as probe in a yeast 2-hybrid screen, Liu and McKeehan (2002) cloned VCY2IP1 (BPY2IP1), which they called C19ORF5, from a liver cDNA library.
The deduced 672-amino acid protein is proline-rich (12.8%) and contains an arginine-rich potential RNA-binding motif. VCY2IP1 shares significant homology with several microtubule-associated proteins. Northern blot analysis revealed a major transcript of about 3 kb in all 12 tissues tested. Additional less-abundant transcripts were detected in some tissues.The International Radiation Hybrid Mapping Consortium mapped the VCY2IP1 gene to chromosome 19.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG125Hu01 Recombinant Microtubule Associated Protein 1S (MAP1S) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG125Hu01 Polyclonal Antibody to Microtubule Associated Protein 1S (MAP1S) WB; IHC; ICC; IP.
Assay Kits SEG125Hu ELISA Kit for Microtubule Associated Protein 1S (MAP1S) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Associated Protein 1S (MAP1S) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Associated Protein 1S (MAP1S) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Associated Protein 1S (MAP1S) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Associated Protein 1S (MAP1S) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Associated Protein 1S (MAP1S) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Associated Protein 1S (MAP1S) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Associated Protein 1S (MAP1S) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Associated Protein 1S (MAP1S) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Associated Protein 1S (MAP1S) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Associated Protein 1S (MAP1S) ELISA Kit Customized Service Offer
  1. "Identification and characterization of a VCY2 interacting protein-1; VCY2IP-1, a MAP-like protein."Biol. Reprod. 70:775-784(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Microtubule-associated protein 8 contains two microtubule binding sites."Biochem. Biophys. Res. Commun. 339:172-179(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity."Genomics 79:124-136(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells."In Vitro Cell. Dev. Biol. Anim. 38:582-594(2002) [PubMed] [Europe PMC] [Abstract]
  9. "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics."Cancer Res. 64:4112-4116(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Putative tumor suppressor RASSF1 interactive protein and cell death inducer C19ORF5 is a DNA binding protein."Biochem. Biophys. Res. Commun. 332:670-676(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5."Cancer Res. 65:1830-1838(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Distinct structural domains within C19ORF5 support association with stabilized microtubules and mitochondrial aggregation and genome destruction."Cancer Res. 65:4191-4201(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  14. "The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain."Biochem. Biophys. Res. Commun. 361:127-132(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Depletion of the Ras association domain family 1, isoform A-associated novel microtubule-associated protein, C19ORF5/MAP1S, causes mitotic abnormalities."Cancer Res. 67:492-500(2007) [PubMed] [Europe PMC] [Abstract]
  16. "MAP1 structural organization in Drosophila: in vivo analysis of FUTSCH reveals heavy- and light-chain subunits generated by proteolytic processing at a conserved cleavage site."Biochem. J. 414:63-71(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Nemitin, a novel Map8/Map1s interacting protein with Wd40 repeats."PLoS ONE 7:E33094-E33094(2012) [PubMed] [Europe PMC] [Abstract]
  27. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]