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Amyloid Beta Precursor Like Protein 1 (APLP1)

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Amyloid Beta Precursor Like Protein 1 (APLP1)
CCC G121
HGNC 597
MGI 88046
PubMed 21574595
RGD 69257
UniProt P51693
Wiki APLP1
APLP1 encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
APLP1 and APLP2 double knockout mice display hypoglycemia and hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG121Hu01 Recombinant Amyloid Beta Precursor Like Protein 1 (APLP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG121Hu21 Monoclonal Antibody to Amyloid Beta Precursor Like Protein 1 (APLP1) WB; IHC; ICC; IP.
PAG121Hu01 Polyclonal Antibody to Amyloid Beta Precursor Like Protein 1 (APLP1) WB; IHC; ICC; IP.
Assay Kits SEG121Hu ELISA Kit for Amyloid Beta Precursor Like Protein 1 (APLP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG121Mu01 Recombinant Amyloid Beta Precursor Like Protein 1 (APLP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPG121Mu02 Recombinant Amyloid Beta Precursor Like Protein 1 (APLP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG121Mu01 Polyclonal Antibody to Amyloid Beta Precursor Like Protein 1 (APLP1) WB; IHC; ICC; IP.
PAG121Mu02 Polyclonal Antibody to Amyloid Beta Precursor Like Protein 1 (APLP1) WB; IHC; ICC; IP.
Assay Kits SEG121Mu ELISA Kit for Amyloid Beta Precursor Like Protein 1 (APLP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amyloid Beta Precursor Like Protein 1 (APLP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amyloid Beta Precursor Like Protein 1 (APLP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amyloid Beta Precursor Like Protein 1 (APLP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amyloid Beta Precursor Like Protein 1 (APLP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amyloid Beta Precursor Like Protein 1 (APLP1) ELISA Kit Customized Service Offer
  1. "Human amyloid precursor-like protein 1 -- cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid."Eur. J. Biochem. 250:354-363(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1."Hum. Genet. 102:192-196(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density."Brain Res. Mol. Brain Res. 32:36-44(1995) [PubMed] [Europe PMC] [Abstract]
  6. "The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily."J. Biol. Chem. 269:26618-26621(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein."J. Biol. Chem. 274:2243-2254(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Evidence for a copper-binding superfamily of the amyloid precursor protein."Biochemistry 41:9310-9320(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  10. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
  11. "The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization."Biochemistry 50:5453-5464(2011) [PubMed] [Europe PMC] [Abstract]