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Adaptor Related Protein Complex 2 Beta 1 (AP2b1)

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ADTB2; AP105B; AP2-BETA; CLAPB1; Clathrin assembly protein complex 2 beta large chain; Plasma membrane adaptor HA2/AP2 adaptin beta subunit

Adaptor Related Protein Complex 2 Beta 1 (AP2b1)
CCC G106
HGNC 563
MGI 1919020
PubMed 21988490
RGD 71048
UniProt P63010
Wiki AP2B1
AP2b1 is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene.
The beta adaptin subunit of the clathrin coat assembly complex, also referred to as AP2-beta, was cloned from human, rat and bovine cDNA libraries by Ponnambalam et al. (1990), who found that the predicted 937-amino acid proteins are totally conserved between species.Druck et al. (1995) used a probe from the 3-prime UTR of the human cDNA to map the gene to chromosome 17. Hybrids with portions of chromosome 17 were then used to localize CLAPB1 to 17q11.2-q12.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG106Hu01 Recombinant Adaptor Related Protein Complex 2 Beta 1 (AP2b1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 2 Beta 1 (AP2b1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 2 Beta 1 (AP2b1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 2 Beta 1 (AP2b1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 2 Beta 1 (AP2b1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Related Protein Complex 2 Beta 1 (AP2b1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 2 Beta 1 (AP2b1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 2 Beta 1 (AP2b1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 2 Beta 1 (AP2b1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 2 Beta 1 (AP2b1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Related Protein Complex 2 Beta 1 (AP2b1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 2 Beta 1 (AP2b1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 2 Beta 1 (AP2b1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 2 Beta 1 (AP2b1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 2 Beta 1 (AP2b1) ELISA Kit Customized Service Offer
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  2. "Expression of a novel beta adaptin subunit mRNA splice variant in human testes."Asian J. Androl. 7:179-188(2005) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binding site in beta 2-adaptin."J. Biol. Chem. 277:9247-9254(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit."Mol. Biol. Cell 13:4001-4012(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network."Cell Struct. Funct. 28:419-429(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin."J. Biol. Chem. 278:47357-47360(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Adaptors for clathrin coats: structure and function."Annu. Rev. Cell Dev. Biol. 20:153-191(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference."J. Biol. Chem. 279:16657-16661(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein."J. Biol. Chem. 280:19270-19280(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex."J. Cell Sci. 119:2321-2331(2006) [PubMed] [Europe PMC] [Abstract]
  13. "ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin."Cell. Signal. 19:2370-2378(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex."J. Cell Sci. 120:1723-1732(2007) [PubMed] [Europe PMC] [Abstract]
  15. "The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway."J. Cell Sci. 121:4008-4017(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  17. "c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway."Cell. Signal. 21:103-110(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  19. "The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery."J. Biol. Chem. 285:10627-10637(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."Nat. Cell Biol. 14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
  22. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "The structure and function of the beta 2-adaptin appendage domain."EMBO J. 19:4216-4227(2000) [PubMed] [Europe PMC] [Abstract]
  25. "Molecular architecture and functional model of the endocytic AP2 complex."Cell 109:523-535(2002) [PubMed] [Europe PMC] [Abstract]
  26. "Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly."Dev. Cell 10:329-342(2006) [PubMed] [Europe PMC] [Abstract]
  27. "Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly."PLoS Biol. 4:E262-E262(2006) [PubMed] [Europe PMC] [Abstract]
  28. "A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex."Nature 456:976-979(2008) [PubMed] [Europe PMC] [Abstract]